Calpain-1 and calpain-2: the yin and yang of synaptic plasticity and neurodegeneration
Many signaling pathways participate in both synaptic plasticity and neuronal degeneration.
While calpains participate in these phenomena, very few studies have evaluated the …
While calpains participate in these phenomena, very few studies have evaluated the …
Regulation of NMDA glutamate receptor functions by the GluN2 subunits
The N‐methyl‐D‐aspartate receptors (NMDARs) are ionotropic glutamate receptors that
mediate the flux of calcium (Ca2+) into the post‐synaptic compartment. Ca2+ influx …
mediate the flux of calcium (Ca2+) into the post‐synaptic compartment. Ca2+ influx …
Synaptic dysfunction in ALS and FTD: anatomical and molecular changes provide insights into mechanisms of disease
PA Gelon, PA Dutchak, CF Sephton - Frontiers in Molecular …, 2022 - frontiersin.org
Synaptic loss is a pathological feature of all neurodegenerative diseases including
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). ALS is a disease of …
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). ALS is a disease of …
MAGUKs: multifaceted synaptic organizers
Highlights•PSD-95 and PSD-93 are essential for PSD structure.•SAP102 plays a role in
clearing NMDARs from the synapse.•PSD-95 sculpts protein content at the PSD.•PSD-93 …
clearing NMDARs from the synapse.•PSD-95 sculpts protein content at the PSD.•PSD-93 …
AMPA receptors and their minions: auxiliary proteins in AMPA receptor trafficking
D Bissen, F Foss, A Acker-Palmer - Cellular and Molecular Life Sciences, 2019 - Springer
To correctly transfer information, neuronal networks need to continuously adjust their
synaptic strength to extrinsic stimuli. This ability, termed synaptic plasticity, is at the heart of …
synaptic strength to extrinsic stimuli. This ability, termed synaptic plasticity, is at the heart of …
AMPA-silent synapses in brain development and pathology
Synapses are constantly generated at a high rate in the developing, prepubescent brain.
Newly generated glutamatergic synapses lack functional AMPA receptor-mediated …
Newly generated glutamatergic synapses lack functional AMPA receptor-mediated …
Dynamic regulation of N-methyl-d-aspartate (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors by posttranslational modifications
MP Lussier, A Sanz-Clemente, KW Roche - Journal of Biological Chemistry, 2015 - ASBMB
Many molecular mechanisms underlie the changes in synaptic glutamate receptor content
that are required by neuronal networks to generate cellular correlates of learning and …
that are required by neuronal networks to generate cellular correlates of learning and …
Glutamatergic synapses in neurodevelopmental disorders
Neurodevelopmental disorders (NDDs) are a group of diseases whose symptoms arise
during childhood or adolescence and that impact several higher cognitive functions such as …
during childhood or adolescence and that impact several higher cognitive functions such as …
Distinct roles for μ-calpain and m-calpain in synaptic NMDAR-mediated neuroprotection and extrasynaptic NMDAR-mediated neurodegeneration
Prolonged calpain activation is widely recognized as a key component of
neurodegeneration in a variety of pathological conditions. Numerous reports have also …
neurodegeneration in a variety of pathological conditions. Numerous reports have also …
Co-agonists differentially tune GluN2B-NMDA receptor trafficking at hippocampal synapses
The subunit composition of synaptic NMDA receptors (NMDAR), such as the relative content
of GluN2A-and GluN2B-containing receptors, greatly influences the glutamate synaptic …
of GluN2A-and GluN2B-containing receptors, greatly influences the glutamate synaptic …