Preclinical challenges in proton minibeam radiotherapy: physics and biomedical aspects

G Datzmann, M Sammer, S Girst, M Mayerhofer… - Frontiers in …, 2020 - frontiersin.org
The concept of spatial fractionation in radiotherapy was developed for better sparing of
normal tissue in the entrance channel of radiation. Spatial fractionation utilizing proton …

High gradient linac for proton therapy

S Benedetti, A Grudiev, A Latina - Physical Review Accelerators and Beams, 2017 - APS
Proposed for the first time almost 30 years ago, the research on radio frequency linacs for
hadron therapy experienced a sparkling interest in the past decade. The different projects …

Radiophotoluminescence of color centers in lithium fluoride for novel radiation detectors in proton-beam diagnostics and clinical dosimetry

RM Montereali, E Nichelatti, M Piccinini… - ECS Journal of Solid …, 2021 - iopscience.iop.org
The peculiar photoluminescence properties of radiation-induced electronic defects in lithium
fluoride (LiF), known as color centers, are well known for applications in tunable lasers and …

Additive Manufacturing of Side-Coupled Cavity Linac Structures from Pure Copper: A First Concept

M Mayerhofer, S Brenner, R Helm, S Gruber, E Lopez… - Instruments, 2023 - mdpi.com
Compared to conventional manufacturing, additive manufacturing (AM) of radio frequency
(RF) cavities has the potential to reduce manufacturing costs and complexity and to enable …

Beam commissioning of the 35 MeV section in an intensity modulated proton linear accelerator for proton therapy

L Picardi, A Ampollini, G Bazzano, E Cisbani… - … Review Accelerators and …, 2020 - APS
This paper presents the experimental results on the Terapia Oncologica con Protoni-
Intensity Modulated Proton Linear Accelerator (TOP-IMPLART) beam that is currently …

Improving Fabrication and Performance of Additively Manufactured RF Cavities by Employing Co-Printed Support Structures and Their Subsequent Removal

M Mayerhofer, S Brenner, M Doppler, L Catarino… - Instruments, 2024 - mdpi.com
The enormous potential of additive manufacturing (AM), particularly laser powder bed fusion
(L-PBF), to produce radiofrequency cavities (cavities) has already been demonstrated …

Magnetically focused 70 MeV proton minibeams for preclinical experiments combining a tandem accelerator and a 3 GHz linear post‐accelerator

M Mayerhofer, G Datzmann, A Degiovanni… - Medical …, 2021 - Wiley Online Library
Purpose Radiotherapy plays an important role for the treatment of tumor diseases in two‐
thirds of all cases, but it is limited by side effects in the surrounding healthy tissue. Proton …

Proton beam spatial distribution and Bragg peak imaging by photoluminescence of color centers in lithium fluoride crystals at the TOP-IMPLART linear accelerator

M Piccinini, C Ronsivalle, A Ampollini… - Nuclear Instruments and …, 2017 - Elsevier
Solid-state radiation detectors based on the photoluminescence of stable point defects in
lithium fluoride crystals have been used for advanced diagnostics during the commissioning …

Longitudinally heterogeneous tumor dose optimizes proton broadbeam, interlaced minibeam, and FLASH therapy

M Sammer, A Rousseti, S Girst, J Reindl, G Dollinger - Cancers, 2022 - mdpi.com
Simple Summary The aim of any kind of external radiation therapy is to control a tumor with
the highest possible probability of the lowest possible side effects. Here, we study further …

Radiobiology of Combining Radiotherapy with Other Cancer Treatment Modalities

V Ahire, N Ahmadi Bidakhvidi, T Boterberg… - Radiobiology …, 2023 - Springer
In this chapter, we address the role of radiation as treatment modality in the context of
oncological treatments given to patients. Physical aspects of the use of ionizing radiation …