Malaria, in particular infection with P. falciparum (the most lethal of the human malaria
parasite species, responsible for nearly one million deaths every year), is one of the most …

Quinoline-containing compounds, such as quinine and chloroquine, have a long-standing
history as potent antimalarial agents. However, the increasing resistance of the Plasmodium …

The application of quinoline-based compounds for the treatment of malaria infections is
hampered by drug resistance. Drug resistance has led to the combination of quinolines with …

Unnatural amino acids (UAAs) are valuable building blocks in the manufacture of a wide
range of pharmaceuticals. UAAs exhibit biological activity as free acids and they can be …

Molecular Hybridization is an approach in rational drug design where new chemical entities
are obtained by combining two or more pharmacophoric units from different bioactive …

Malaria remains one of the major health problems worldwide. The lack of an effective
vaccine and the increasing resistance of Plasmodium to the approved antimalarial drugs …

Discovery and development of antimalarial drugs have long been dominated by single-
target therapy. Continuous effort has been made to explore and identify different targets in …

Complex diseases comprises of highly complicated etiology resulting in limited applicability
of conventional targeted therapies. Consequently, conventional medicinal compounds suffer …

The newly emerged severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) cause
life‐threatening diseases in millions of people worldwide, in particular, in patients with …

Malaria is a tropical disease, leading to around half a million deaths annually. Antimalarials
such as quinolines are crucial to fight against malaria, but malaria control is extremely …