Neurodegenerative disorders (NDs) affect essential functions not only in the CNS, but also
cause persistent gut dysfunctions, suggesting that they have an impact on both CNS and gut …

The gut microbiota plays a key role in host health and disease, particularly through their
interactions with the immune system. Intestinal homeostasis is dependent on the symbiotic …

Activation of scramblases is one of the mechanisms that regulates the exposure of
phosphatidylserine to the cell surface, a process that plays an important role in tumour …

Curcumin has shown good efficacy in mice with experimental colitis and in patients with
ulcerative colitis, but the mechanism of action through the regulation of M1/M2 macrophage …

Ulcerative colitis is a chronic condition in which a dysregulated immune response
contributes to the acute intestinal inflammation of the colon. Current clinical therapies often …

Inflammation is a life-saving immune reaction occurring in response to invading pathogens.
Nonetheless, inflammation can also occur in an uncontrolled, unrestricted manner, leading …

Background Classically activated M1 macrophages, characterized by aberrant glycolysis
and secretion of inflammatory cytokines, play pivotal roles in inflammatory diseases …

Objective To explore the effect and potential mechanism of LncRNA MIR4435-2HG on
macrophage polarization and intestinal inflammation in ulcerative colitis (UC). Methods …

Cepharanthine (CEP), a bisbenzylisoquinoline alkaloid from tubers of Stephania, protects
against some inflammatory diseases. Aconitate decarboxylase 1 (ACOD1) is also known as …

Macrophages are versatile cells of the innate immune system that work by altering their pro-
or anti-inflammatory features. Their dysregulation leads to inflammatory disorders such as …