The malignant tumor is a multi-etiological, systemic and complex disease characterized by
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …

While commonly known for degradation of the extracellular matrix, matrix metalloproteinases
(MMPs) exhibit broad potential for use in targeting of bioactive and imaging agents in cancer …

Abstract Background Cancer-associated fibroblasts (CAFs), the most abundant cells in the
tumor microenvironment, have prominent roles in the development of solid tumors as …

Elevated growth in breast cancer (BC) activates hypoxia‐inducible factor (HIF1a) and
downstream, facilitative glucose transporter 1 (GLUT1), which can be visualized with 2 …

Objective: The objective of this study was to analyze the effects of lysyl oxidase (LOX) on the
expression and enzyme activity of the matrix metalloproteinases 2 (MMP-2) and 9 (MMP-9) …

Lysyl oxidase (LOX) family genes catalyze collagen cross-link formation. To determine the
effects of lysyl oxidase-like 4 (LOXL4) expression on breast tumor formation and metastasis …

Lysyl oxidase (LOX) is a copper‐dependent monoamine oxidase whose primary function is
the covalent cross‐linking of collagen in the extracellular matrix (ECM). Evidence has shown …

The lysyl oxidase (LOX) family proteins are secreted copper-dependent amine oxidases,
comprised of five paralogues: LOX and LOX-like 1-4 (LOXL1-4), which are characterized by …

Breast cancer (BRCA) is a malignant tumor with a high incidence and poor prognosis in
females. However, its pathogenesis remains unclear. In this study, based on bioinformatic …

Background Tumour hypoxia is associated with increased metastasis, invasion, poor
therapy response and prognosis. Most PET radiotracers developed and used for clinical …