Mechanism of the interaction of toxic SOD1 fibrils with two potent polyphenols: Curcumin and quercetin
Amyotrophic lateral sclerosis (ALS) is a debilitating neurodegenerative disease commonly
caused due to the aggregation of superoxide dismutase 1 (SOD1) protein. Finding inhibitors …
caused due to the aggregation of superoxide dismutase 1 (SOD1) protein. Finding inhibitors …
Biophysical and spectroscopical insights into structural modulation of species in the aggregation pathway of superoxide dismutase 1
Abstract Superoxide dismutase 1 (SOD1) aggregation is implicated in the development of
Amyotrophic Lateral Sclerosis (ALS). Despite knowledge of the role of SOD1 aggregation …
Amyotrophic Lateral Sclerosis (ALS). Despite knowledge of the role of SOD1 aggregation …
Myricetin: A potent anti-amyloidogenic polyphenol against superoxide dismutase 1 aggregation
Amyotrophic lateral sclerosis (ALS) is believed to be caused by the aggregation of misfolded
or mutated superoxide dismutase 1 (SOD1). As there is currently no treatment, research into …
or mutated superoxide dismutase 1 (SOD1). As there is currently no treatment, research into …
Effect of flavonoids on the destabilization of α-synuclein fibrils and their conversion to amorphous aggregate: A molecular dynamics simulation and experimental study
The second most prevalent neurodegenerative disease, Parkinson's disease (PD), is
caused by the accumulation and deposition of fibrillar aggregates of the α-Syn into the Lewy …
caused by the accumulation and deposition of fibrillar aggregates of the α-Syn into the Lewy …
Bisdemethoxycurcumin, a novel potent polyphenolic compound, effectively inhibits the formation of amyloid aggregates in ALS-associated hSOD1 mutant (L38R)
ZH Kouhi, B Seyedalipour, S Hosseinkhani… - International Journal of …, 2024 - Elsevier
Protein misfolding is a biological process that leads to protein aggregation. Anomalous
misfolding and aggregation of human superoxide dismutase (hSOD1) into amyloid …
misfolding and aggregation of human superoxide dismutase (hSOD1) into amyloid …
In silico analysis of SOD1 aggregation inhibition modes of tertiary amine pyrazolone and pyrano coumarin ferulate as ALS drug candidates
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, the familial form
(fALS) of which is often cognate to mutations in the antioxidant enzyme Cu/Zn superoxide …
(fALS) of which is often cognate to mutations in the antioxidant enzyme Cu/Zn superoxide …