Schwann cells within the peripheral nervous system possess a remarkable regenerative
potential. Current research shows that peripheral nerve‐associated Schwann cells possess …

Schwann cells develop from the neural crest in a well-defined sequence of events. This
involves the formation of the Schwann cell precursor and immature Schwann cells, followed …

Schwann cell dedifferentiation from a myelinating to a progenitor-like cell underlies the
remarkable ability of peripheral nerves to regenerate following injury. However, the …

The radical response of peripheral nerves to injury (Wallerian degeneration) is the
cornerstone of nerve repair. We show that activation of the transcription factor c-Jun in …

During the development of peripheral nerves, neural crest cells generate myelinating and
non-myelinating glial cells in a process that parallels gliogenesis from the germinal layers of …

After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for
regeneration. Normally providing strong regenerative support, these cells fail in aging …

The cells of the neural crest, often referred to as neural crest stem cells, give rise to a
number of sub-lineages, one of which is Schwann cells, the glial cells of peripheral nerves …

Schwann cell incredible plasticity is a hallmark of the utmost importance following nerve
damage or in demyelinating neuropathies. After injury, Schwann cells undergo …

Myelin is essential to nervous system function, playing roles in saltatory conduction and
trophic support. Oligodendrocytes (OLs) and Schwann cells (SCs) form myelin in the central …

Transforming growth factor beta (TGF-β) proteins are multifunctional cytokines whose neural
functions are increasingly recognized. The machinery of TGF-β signaling, including the …