Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase
Inorganic anions inhibit the metalloenzyme carbonic anhydrase (CA, EC 4.2. 1.1) generally
by coordinating to the active site metal ion. Cyanate was reported as a non-coordinating CA …
by coordinating to the active site metal ion. Cyanate was reported as a non-coordinating CA …
Carbonic anhydrase activators for neurodegeneration: an overview
V Poggetti, S Salerno, E Baglini, E Barresi… - Molecules, 2022 - mdpi.com
Carbonic anhydrases (CAs) are a family of ubiquitous metal enzymes catalyzing the
reversible conversion of CO2 and H2O to HCO3− with the release of a proton. They play an …
reversible conversion of CO2 and H2O to HCO3− with the release of a proton. They play an …
Isocoumarins: a new class of selective carbonic anhydrase IX and XII inhibitors
Isocoumarins, isomeric to comarins which act as effective carbonic anhydrase (CA, EC 4.2.
1.1) inhibitors, were investigated for the first time as inhibitors of this enzyme. A series of 3 …
1.1) inhibitors, were investigated for the first time as inhibitors of this enzyme. A series of 3 …
Discovery of new ureido benzenesulfonamides incorporating 1, 3, 5-triazine moieties as carbonic anhydrase I, II, IX and XII inhibitors
A series of twenty novel ureido benzenesulfonamides incorporating 1, 3, 5-triazine moieties
substituted on one side with aromatic amines and on the other side with dimethylamine …
substituted on one side with aromatic amines and on the other side with dimethylamine …
Fluconazole-induced protein changes in osteogenic and immune metabolic pathways of dental pulp mesenchymal stem cells of osteopetrosis patients
Z Alkhayal, Z Shinwari, A Gaafar, A Alaiya - International Journal of …, 2023 - mdpi.com
Osteopetrosis is a rare inherited disease caused by osteoclast failure, resulting in increasing
bone density in humans. Patients with osteopetrosis possess several dental and cranial …
bone density in humans. Patients with osteopetrosis possess several dental and cranial …
Potent carbonic anhydrase I, II, IX and XII inhibition activity of novel primary benzenesulfonamides incorporating bis-ureido moieties
A novel series of twelve aromatic bis-ureido-substituted benzenesulfonamides was
synthesised by conjugation of aromatic aminobenzenesulfonamides with aromatic bis …
synthesised by conjugation of aromatic aminobenzenesulfonamides with aromatic bis …
Activation of α-, β-, γ-δ-, ζ-and η-class of carbonic anhydrases with amines and amino acids: A review
S Akocak, CT Supuran - Journal of enzyme inhibition and …, 2019 - Taylor & Francis
Eight genetically distinct carbonic anhydrase (EC 4.2. 1.1) enzyme families (α-, β-, γ-δ-, ζ-, η-
, θ-and ι-CAs) were described to date. On the other hand, 16 mammalian α-CA isoforms are …
, θ-and ι-CAs) were described to date. On the other hand, 16 mammalian α-CA isoforms are …
Synthesis, Biological and In Silico Studies of Griseofulvin and Usnic Acid Sulfonamide Derivatives as Fungal, Bacterial and Human Carbonic Anhydrase Inhibitors
A Angeli, A Petrou, V Kartsev, B Lichitsky… - International Journal of …, 2023 - mdpi.com
Carbonic anhydrases (CAs, EC 4.2. 1.1) catalyze the essential reaction of CO2 hydration in
all living organisms, being actively involved in the regulation of a plethora of patho …
all living organisms, being actively involved in the regulation of a plethora of patho …
Synthesis of calix [4] azacrown substituted sulphonamides with antioxidant, acetylcholinesterase, butyrylcholinesterase, tyrosinase and carbonic anhydrase inhibitory …
A series of novel calix [4] azacrown substituted sulphonamide Schiff bases was synthesised
by the reaction of calix [4] azacrown aldehydes with different substituted primary and …
by the reaction of calix [4] azacrown aldehydes with different substituted primary and …
Activation studies with amino acids and amines of a β-carbonic anhydrase from Mammaliicoccus (Staphylococcus) sciuri previously annotated as Staphylococcus …
A β-carbonic anhydrase (CA, EC 4.2. 1.1) previously annotated to be present in the genome
of Staphylococcus aureus, SauBCA, has been shown to belong to another pathogenic …
of Staphylococcus aureus, SauBCA, has been shown to belong to another pathogenic …