Various signaling mechanisms contribute significantly to the development of multiple
cancers. Small molecules with the potential of influencing a wide variety of molecular targets …

Flavonoids are increasingly applied in foods to promote their functional properties, human
health, and overall wellbeing. Luteolin, a polyphenolic plant flavonoid, is recognized as one …

Imbalance of bone homeostasis, with excessive bone resorption compared with bone
formation, leads to the development of progressive osteopenia leading to lower bone …

Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterized by a
progressive-fibrosing phenotype. IPF has been associated with aberrant HDAC activities …

Histone modifications through acetylation are fundamental for remodelling chromatin and
consequently activating gene expression. The imbalance between acetylation and …

Aims Cisplatin is the mainstay of first-line treatment for advanced non-small cell lung cancer
(NSCLC). Accumulating evidence suggests that flavonoids inhibit histone deacetylase …

Prostate cancer (PC) is one of the major impediments affecting men, which leads
approximately 31,620 deaths in both developing and developed countries. Although some …

Epigenetics, including DNA methylation, histone modification, and noncoding RNA
regulation, are physiological regulatory changes that affect gene expression without …

This paper describes the rational development of a series of novel spiroindoline derivatives
endowed with selective inhibitory activity on the HDAC6 isoform. A convenient …

Sirtuins (SIRTs) overexpression serves as a potential therapeutic target for TNBC because it
is associated with bioactivities of cancer stem cells (CSCs), resistance to chemotherapy, and …