Using the comet and micronucleus assays for genotoxicity studies: A review

RP Araldi, TC de Melo, TB Mendes… - Biomedicine & …, 2015 - Elsevier
Physical, chemical and biological agents can act in the DNA, resulting in mutation involved
in cancer. Thus, genotoxic tests are required by regulatory agencies in order to evaluate …

An application of acridine orange fluorescent staining to the micronucleus test

M Hayashi, T Sofuni, M Ishidate Jr - Mutation Research Letters, 1983 - Elsevier
Acridine Orange fluorescent staining was applied to the micronucleus test in mice and rats.
Micronuclei emitted bright green fluorescence and were easily distinguished from …

Guidelines for the conduct of micronucleus assays in mammalian bone marrow erythrocytes

JT MacGregor, JA Heddle, M Hite, BH Margolin… - Mutation Research …, 1987 - Elsevier
This document provides recommended guidelines for performing the mammalian in vivo
bone marrow micronucleus assay. Under appropriate test conditions, measurement of the …

Bone marrow micronucleus assay: a review of the mouse stocks used and their published mean spontaneous micronucleus frequencies

MF Salamone, KH Mavournin - Environmental and Molecular …, 1994 - Wiley Online Library
We have examined published negative control data from 581 papers on micronucleated
bone marrow polychromatic erythrocytes (mnPCE) for differences in mean frequency and …

Safety studies on epigallocatechin gallate (EGCG) preparations. Part 1: genotoxicity

RA Isbrucker, J Bausch, JA Edwards, E Wolz - Food and Chemical …, 2006 - Elsevier
Public interest in green tea has grown recently due to the potential health benefits from its
consumption. Epigallocatechin gallate (EGCG), a principal polyphenolic component of …

Evaluation of the potential in vivo genotoxicity of quercetin

D Utesch, K Feige, J Dasenbrock, TH Broschard… - … /Genetic Toxicology and …, 2008 - Elsevier
Quercetin, a naturally occurring flavonol commonly detected in apples, cranberries,
blueberries, and onions, has been reported to possess antioxidant, anti-carcinogenic, anti …

Acute, subacute toxicity and genotoxic effect of a hydroethanolic extract of the cashew (Anacardium occidentale L.)

NA Konan, EM Bacchi, N Lincopan, SD Varela… - Journal of …, 2007 - Elsevier
Anacardium occidentale L.(Anacardiaceae), popularly known as cajueiro is a native plant to
Brazil, and largely used in popular medicine to treat ulcers, hypertension and diarrhea. In …

Assessment of radio-frequency electromagnetic radiation by the micronucleus test in Bovine peripheral erythrocytes

Z Balode - Science of the Total Environment, 1996 - Elsevier
Previous bioindicative studies in the Skrunda Radio Location Station area have focused on
the somatic influence of electromagnetic radiation on plants, but it is also important to study …

Micronucleus assays

WU Müller, C Streffer - Advances in mutagenesis research, 1994 - Springer
Small, round-shaped structures that stained like the cell nucleus were observed in the
cytoplasm of erythrocytes more than a century ago (Neumann 1869, p. 78; Howell 1891; for …

The bone marrow micronucleus assay: rationale for a revised protocol

MF Salamone, JA Heddle - … Mutagens: Principles and Methods for Their …, 1983 - Springer
From the time it was first recognized that environmental chemicals could damage the genetic
integrity of plants, animals, and, by implication, humans, interest has focused on the …