Cardiovascular effects of caffeic acid and its derivatives: a comprehensive review

H Silva, NMF Lopes - Frontiers in physiology, 2020 - frontiersin.org
Caffeic acid (CA) and its phenethyl ester (CAPE) are naturally occurring hydroxycinnamic
acids with an interesting array of biological activities; eg, antioxidant, anti-inflammatory …

Hydroxycinnamates and their in vitro and in vivo antioxidant activities

F Shahidi, A Chandrasekara - Phytochemistry Reviews, 2010 - Springer
Hydroxycinnamates are among the most widely distributed plant phenylpropanoids present
in the free, conjugated-soluble and insoluble-bound forms. This review will focus on the …

[HTML][HTML] Cardioprotection of CAPE-oNO2 against myocardial ischemia/reperfusion induced ROS generation via regulating the SIRT1/eNOS/NF-κB pathway in vivo and …

D Li, X Wang, Q Huang, S Li, Y Zhou, Z Li - Redox Biology, 2018 - Elsevier
Caffeic acid phenethyl ester (CAPE) could ameliorate myocardial ischemia/reperfusion
injury (MIRI) by various mechanisms, but there hadn't been any reports on that CAPE could …

Caffeic acid phenethyl ester, a promising component of propolis with a plethora of biological activities: A review on its anti‐inflammatory, neuroprotective …

MF Tolba, SS Azab, AE Khalifa, SZ Abdel‐Rahman… - IUBMB …, 2013 - Wiley Online Library
Caffeic acid phenethyl ester (CAPE) is an important active component of honey bee propolis
that possesses a plethora of biological activities. Propolis is used safely in traditional …

[HTML][HTML] Neuroprotective effect of caffeic acid phenethyl ester in a mouse model of Alzheimer's disease involves Nrf2/HO-1 pathway

F Morroni, G Sita, A Graziosi, E Turrini… - Aging and …, 2018 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a progressive pathology, where dementia symptoms gradually
worsen over a number of years. The hallmarks of AD, such as amyloid β-peptide (Aβ) in …

Recent progresses in the pharmacological activities of caffeic acid phenethyl ester

L Lv, H Cui, Z Ma, X Liu, L Yang - Naunyn-Schmiedeberg's Archives of …, 2021 - Springer
The past decades have seen a growing interest in natural products. Caffeic acid phenethyl
ester (CAPE), a flavonoid isolated from honeybee propolis, has shown multiple …

Caffeic acid phenethyl ester (CAPE) ameliorates cisplatin-induced hepatotoxicity in rabbit

A Kart, Y Cigremis, M Karaman, H Ozen - Experimental and Toxicologic …, 2010 - Elsevier
In this study, it was aimed to investigate the protective effect of caffeic acid phenethyl ester
(CAPE) on cisplatin hepatotoxicity. Thirty New Zealand rabbits were divided into 5 groups as …

[HTML][HTML] Dexmedetomidine exerts cardioprotective effect through miR-146a-3p targeting IRAK1 and TRAF6 via inhibition of the NF-κB pathway

L He, Z Wang, R Zhou, W Xiong, Y Yang… - Biomedicine & …, 2021 - Elsevier
Background Myocardial ischemia/reperfusion (I/R) injury is a common cause of mortality.
Cardiac miR-146a is emerging as a potent regulator of myocardial function …

Caffeic acid phenethyl ester ameliorates calcification by inhibiting activation of the AKT/NF-κB/NLRP3 inflammasome pathway in human aortic valve interstitial cells

M Liu, F Li, Y Huang, T Zhou, S Chen, G Li… - Frontiers in …, 2020 - frontiersin.org
Calcific aortic valve disease (CAVD) occurs via a pathophysiological process that includes
inflammation-induced osteoblastic differentiation of aortic valvular interstitial cells (AVICs) …

Caffeic acid and its derivative caffeic acid phenethyl ester as potential therapeutic compounds for cardiovascular diseases: A systematic review

A Nasimi Shad, I Akhlaghipour… - Archiv der …, 2024 - Wiley Online Library
Cardiovascular diseases (CVDs) contribute to major public health issues. Some studies
have found that caffeic acid (CA) and caffeic acid phenethyl ester (CAPE) may effectively …