As the ubiquitin–proteasome system (UPS) regulates almost every biological process, the
dysregulation or aberrant expression of the UPS components causes many pathological …

With an understanding of immunity in the tumor microenvironment, immunotherapy turns out
to be a powerful tool in the clinic to treat many cancers. The strategies applied in cancer …

Primary liver cancer is the fifth most common malignancy and the third leading cause of
cancer death worldwide. Although current advances in the treatment of liver cancer, the …

Many drug and therapeutic modalities have emerged over the past few years. However,
successful commercialization is dependent on their safety and efficacy evaluations. Several …

Despite the progress in the comprehension of LC progression, risk, immunologic control,
and treatment choices, it is still the primary cause of cancer-related death. LC cells possess …

Background Excessive hepatic glycogen accumulation benefits tumorigenesis and cancer
cell survival. We previously reported that BMP4 has the strongest ability to promote …

Organoids are stem cell-derived, self-organizing, 3D structures. Compared to the
conventional 2D cell culture method, 3D cultured organoids contain a variety of cell types …

The transfection efficiency and stability of the delivery vehicles of plasmid DNA (pDNA) are
critical metrics to ensure high-quality and high-yield production of viral vectors. We …

Abstract Acetalated dextran (Ac-Dex) nanoparticles are currently of immense interest due to
their sharp pH-responsive nature and high biodegradability. Ac-Dex nanoparticles are often …

Cholangiocarcinoma (CCA) is a biliary tree malignancy with a dismal prognosis. Tumor
microenvironment (TME), including cancer-associated fibroblasts (CAFs) has been shown to …