Metabolic enzymes of helminth parasites: potential as drug targets

D J. Timson - Current Protein and Peptide Science, 2016 - benthamdirect.com
Metabolic pathways that extract energy from carbon compounds are essential for an
organism's survival. Therefore, inhibition of enzymes in these pathways represents a …

Interplay between protein thermal flexibility and kinetic stability

AG Quezada, AJ Díaz-Salazar, N Cabrera… - Structure, 2017 - cell.com
Kinetic stability is a key parameter to comprehend protein behavior and it plays a central role
to understand how evolution has reached the balance between function and stability in cell …

Characterization of a recombinant mu-class glutathione S-transferase from Taenia solium

N Vibanco-Pérez, L Jimenez… - Parasitology …, 2002 - Springer
A Taenia solium larval glutathione S-transferase fraction (SGSTF), composed of two proteins
with M r 25,500 (SGSTM1) and 26,500 (SGSTM2), was purified by GSH-sepharose. Its N …

Native aggregation is a common feature among triosephosphate isomerases of different species

M Rodríguez-Bolaños, H Miranda-Astudillo… - Scientific Reports, 2020 - nature.com
Triosephosphate isomerase (TIM) is an enzyme of the glycolysis pathway which exists in
almost all types of cells. Its structure is the prototype of a motif called TIM-barrel or (α/β) 8 …

Cloning, production and characterisation of a recombinant Cu/Zn superoxide dismutase from Taenia solium

A Castellanos-González, L Jiménez, A Landa - International journal for …, 2002 - Elsevier
A full-length complementary DNA clone encoding a cytosolic Cu/Zn superoxide dismutase
with a Mr of 15,588 Da was isolated from a Taenia solium larvae complementary DNA …

Characterization of triosephosphate isomerase from Mycoplasma gallisepticum

S Bao, D Chen, S Yu, H Chen, L Tan… - FEMS Microbiology …, 2015 - academic.oup.com
Triosephosphate isomerase (Tpi) is a glycolytic enzyme that is essential for efficient energy
production in many pathogens. However, its function in Mycoplasma gallisepticum has not …

Structural and biochemical characterization of a recombinant triosephosphate isomerase from Rhipicephalus (Boophilus) microplus

J Moraes, R Arreola, N Cabrera, L Saramago… - Insect biochemistry and …, 2011 - Elsevier
Triosephosphate isomerase (TIM) is an enzyme with a role in glycolysis and
gluconeogenesis by catalyzing the interconversion between glyceraldehyde 3-phosphate …

Cooperative kinetics of the recombinant glutathione transferase of Taenia solium and characterization of the enzyme

A Torres-Rivera, A Landa - Archives of biochemistry and biophysics, 2008 - Elsevier
Glutathione transferases (GSTs) are essential enzymes in many organisms due their diverse
functions and, in helminths they are the main detoxification system. For Taenia solium, two …

Expression and activity of glycogen synthase kinase during vitellogenesis and embryogenesis of Rhipicephalus (Boophilus) microplus

C Logullo, WH Witola, C Andrade, L Abreu… - Veterinary …, 2009 - Elsevier
Glycogen synthase kinase 3 (GSK-3) is classically described as a key enzyme involved in
glycogen metabolism in mammals. GSK-3 belongs to a highly conserved family of …

Cloning, overexpression and characterization of Leishmania donovani triosephosphate isomerase

K Kumar, P Bhargava, U Roy - Experimental parasitology, 2012 - Elsevier
Triosephosphate isomerase (TIM) is a major enzyme in the glycolytic pathway, which
catalyzes the interconversion of glyceraldehyde 3-phosphate to dihydroxyacetone …