Targeted therapy for inflammatory diseases with mesenchymal stem cells and their derived exosomes: from basic to clinics

S Wang, B Lei, E Zhang, P Gong, J Gu… - International Journal …, 2022 - Taylor & Francis
Inflammation is a beneficial and physiological process, but there are a number of
inflammatory diseases which have detrimental effects on the body. In addition, the drugs …

When origin matters: properties of mesenchymal stromal cells from different sources for clinical translation in kidney disease

S Calcat-i-Cervera, C Sanz-Nogués, T O'Brien - Frontiers in Medicine, 2021 - frontiersin.org
Advanced therapy medicinal products (ATMPs) offer new prospects to improve the treatment
of conditions with unmet medical needs. Kidney diseases are a current major health concern …

Mesenchymal stem cell protects injured renal tubular epithelial cells by regulating mTOR-mediated Th17/Treg axis

Y Luo, J Guo, P Zhang, YC Cheuk, Y Jiang… - Frontiers in …, 2021 - frontiersin.org
The increase in T helper 17 cell (Th17)-mediated pro-inflammatory response and decrease
in regulatory T cell (Treg)-mediated anti-inflammatory effect aggravate renal tubular …

A supramolecular hydrogel based on the combination of YIGSR and RGD enhances mesenchymal stem cells paracrine function via integrin α2β1 and PI3K/AKT …

Q Han, S Ai, Q Hong, C Zhang, Y Song, X Wang… - Chemical Engineering …, 2022 - Elsevier
Mesenchymal stem cell (MSC) transplantation has emerged as a promising strategy for the
treatment of acute kidney injury (AKI). However, MSC-based therapies are limited by their …

Stem cell-derived extracellular vesicles as potential therapeutic approach for acute kidney injury

M Quaglia, G Merlotti, A Colombatto, S Bruno… - Frontiers in …, 2022 - frontiersin.org
Acute kidney injury is a frequent complication of hospitalized patients and significantly
increases morbidity and mortality, worsening costs and length of hospital stay. Despite this …

Release of HMGB1 in Podocytes Exacerbates Lipopolysaccharide‐Induced Acute Kidney Injury

Z Gao, L Lu, X Chen - Mediators of inflammation, 2021 - Wiley Online Library
Objective. Acute kidney injury (AKI) usually occurs during sepsis. Inflammation factors, such
as high‐mobility group box 1 (HMGB1), are dramatically upregulated under septic …

CD8+ CD103+ iTregs protect against ischemia-reperfusion-induced acute kidney Injury by inhibiting pyroptosis

Q Chen, X Zhang, H Yang, G Luo, X Zhou, Z Xu, A Xu - Apoptosis, 2024 - Springer
The occurrence of acute kidney injury (AKI) is elevated, one of the main causes is ischemia-
reperfusion (I/R). However, no specific therapy is currently available to treat I/R-induced AKI …

Immunomodulatory effects of mesenchymal stem cells on drug-induced acute kidney injury

Q Han, X Wang, X Ding, J He, G Cai, H Zhu - Frontiers in Immunology, 2021 - frontiersin.org
Drug-induced nephrotoxicity is an important and increasing cause of acute kidney injury
(AKI), which accounts for approximately 20% of hospitalized patients. Previous reviews …

Therapeutic Effects of Genetically Modified Wharton's Jelly Mesenchymal Stem Cells Expressing Erythropoietin on Breast Cancer-related Anemia in Mice Model

M Estiri, B Estiri, A Fallah, M Aghazadeh, A Sedaqati… - 2021 - researchsquare.com
Cancer-related anemia (CRA) negatively influences cancer patients' survival, disease
progression, treatment efficacy, and quality of life (QOL). Current treatments such as iron …