Multifaceted roles of crocin, phytoconstituent of Crocus sativus Linn. In cancer treatment: An expanding horizon

Y Mishra, V Mishra - South African Journal of Botany, 2023 - Elsevier
Despite the proliferation of medications and therapies for cancer patients, cancer is an
illness that significantly influences the expectancy and quality of life. Globally, there is a …

[HTML][HTML] Saffron as a Promising Therapy for Inflammatory Bowel Disease

M Rashid, R Rashid, S Saroya, M Deverapalli, H Brim… - Nutrients, 2024 - mdpi.com
Inflammatory bowel disease (IBD) is a chronic inflammatory illness of the gastrointestinal
tract (GI), characterized by recurrent episodes of inflammation and tissue destruction. It …

A novel pectin-like polysaccharide from Crocus sativus targets Galectin-3 to inhibit hepatic stellate cells activation and liver fibrosis

B Tang, C Jin, M Li, S Liu, X Zhang, J Li, K Ding… - Carbohydrate …, 2025 - Elsevier
Liver fibrosis may lead to cirrhosis and even cancer without effective clinical medicine
available. Previous studies demonstrated that galactan-containing pectins or pectin-like …

Microbiomic and Metabolomic Analyses Unveil the Protective Effect of Saffron in a Mouse Colitis Model

G Singh, H Brim, Y Haileselassie, S Varma… - Current Issues in …, 2023 - mdpi.com
Despite the existence of effective drugs used to treat inflammatory bowel disease (IBD),
many patients fail to respond or lose response over time. Further, many drugs can carry …

[HTML][HTML] Oral administration of crocin-loaded solid lipid nanoparticles inhibits neuroinflammation in a rat model of epileptic seizures by activating SIRT1 expression

S Kakebaraei, M Gholami, TZ Nasta… - Research in …, 2024 - journals.lww.com
Background and purpose: Epilepsy is a group of chronic neurological diseases caused by a
complex set of neuronal hyper electrical activities and oxidative stress of neurons. Crocin is …

Inhibitory effect of saffron components on hIAPP fibrils formation; a molecular dynamics simulation study

A Kordzadeh, M Minaeian, AR SA - Computational and Theoretical …, 2024 - Elsevier
Molecular dynamics simulations were used to investigate how saffron components inhibited
the formation of human islet amyloid polypeptide's fibrils (hIAPP). hIAPP in a water medium …

Induction of stigma-like structures in saffron (Crocus sativus L.): Exploring factors and metabolite analysis

P Mahmoudi, A Moieni, M Khayam Nekouei, M Mardi… - PloS one, 2025 - journals.plos.org
Saffron (Crocus sativus L.) has held significant cultural and medicinal value since the Greek-
Minoan civilization. As a triploid spice with vegetative propagation from the Iridaceae family …

[HTML][HTML] Saffron regulates bile acid metabolism and participates in the molecular mechanisms of cholestasis-induced liver injury through the mediation of the ERK …

W Wang, W Xiong, N Li, J Xia, C Yang, S Xiong… - Journal of Functional …, 2024 - Elsevier
Bilirubin-induced liver injury is a severe health issue with inadequate treatment. This study
examined whether saffron's Crocin and Crocetin could reduce bile stasis-induced liver …

Trace Toxins: The Key Component of a Healthful Diet

J Stone, R Mason, J Mitrofanis… - Dose …, 2024 - journals.sagepub.com
Although it is well established that a vegetable-rich (Mediterranean) diet is associated with
health benefits in later life, the mechanisms and biological origins of this benefit are not well …

Bioactive compounds in the nutrition of peri-and postmenopausal women within the concept of 4P-medicine

AV Vorontsova, AV Pogozheva - Voprosy Pitaniia, 2023 - europepmc.org
An updated consensus statement from the European Menopause and Andropause Society
noted that a woman's quality of life may decline during peri-and post-menopause as a result …