Rheumatoid arthritis (RA) is a chronic inflammatory joint disease that can lead to clinical
manifestations of systemic diseases. Its leading features include chronic synovial …

Rheumatoid arthritis (RA), a common autoimmune disease, is characterized by a highly
coordinated inflammatory response that involves innate and adaptive immunity. One of the …

Periodontal disease is more common in individuals with rheumatoid arthritis (RA) who have
detectable anti-citrullinated protein antibodies (ACPAs), implicating oral mucosal …

The global COVID-19 pandemic has the potential to severely affect those with rheumatic
diseases or who are taking immunosuppressive therapies. Information is lacking as to how …

Peptidylarginine deiminases (PADs) have an important role in the pathogenesis of
rheumatoid arthritis (RA) owing to their ability to generate citrullinated proteins—the …

Peptidylarginine deiminases (PADs) are calcium-dependent enzymes that mediate
citrullination, an irreversible post-translational modification (PTM). PAD enzymes have …

The tumor immune microenvironment (TIME) controls tumorigenesis. Neutrophils are
important components of TIME and control tumor progression and therapy resistance …

The contribution of NETs (neutrophil extracellular traps) to thrombus formation has been
intensively documented in both arterial and venous thrombosis in mice. We previously …

Thrombosis remains a major problem in our society, manifesting across multiple
demographic groups and with high associated morbidity and mortality. Thrombus …

The post-translational modification of proteins expands the regulatory scope of the proteome
far beyond what is achievable through genome regulation. The field of protein citrullination …