Vascular smooth muscle cells in atherosclerosis: time for a re-assessment

MOJ Grootaert, MR Bennett - Cardiovascular research, 2021 - academic.oup.com
Vascular smooth muscle cells (VSMCs) are key participants in both early and late-stage
atherosclerosis. VSMCs invade the early atherosclerotic lesion from the media, expanding …

The fibroblast growth factor signaling pathway

DM Ornitz, N Itoh - Wiley Interdisciplinary Reviews …, 2015 - Wiley Online Library
The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is
comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF …

Fibroblast growth factor receptor signalling dysregulation and targeting in breast cancer

C Francavilla, CS O'Brien - Open Biology, 2022 - royalsocietypublishing.org
Fibroblast Growth Factor Receptor (FGFR) signalling plays a critical role in breast embryonal
development, tissue homeostasis, tumorigenesis and metastasis. FGFR, its numerous FGF …

Myocardin in biology and disease

JM Miano - Journal of biomedical research, 2014 - pmc.ncbi.nlm.nih.gov
Myocardin (MYOCD) is a potent transcriptional coactivator that functions primarily in cardiac
muscle and smooth muscle through direct contacts with serum response factor (SRF) over …

An overview of potential molecular mechanisms involved in VSMC phenotypic modulation

MJ Zhang, Y Zhou, L Chen, YQ Wang, X Wang… - Histochemistry and cell …, 2016 - Springer
The fully differentiated medial vascular smooth muscle cells (VSMCs) of mature vessels
keep quiescent and contractile. However, VSMC can exhibit the plasticity in phenotype …

Down-regulation of miR-23b induces phenotypic switching of vascular smooth muscle cells in vitro and in vivo

C Iaconetti, S De Rosa, A Polimeni… - Cardiovascular …, 2015 - academic.oup.com
Aims Phenotypic switch of vascular smooth muscle cells (VSMCs) plays a key role in the
pathogenesis of different vascular diseases, such as atherosclerosis and restenosis after …

Fibroblast growth factor signaling in the vasculature

X Yang, L Liaw, I Prudovsky, PC Brooks, C Vary… - Current atherosclerosis …, 2015 - Springer
Despite their discovery as angiogenic factors and mitogens for endothelial cells more than
30 years ago, much remains to be determined about the role of fibroblast growth factors …

AKT mediates adiponectin-dependent regulation of VSMC phenotype

AE Cullen, AM Centner, R Deitado, A Ismaeel… - Cells, 2023 - mdpi.com
Adiponectin (adipoq), the most abundant hormone in circulation, has many beneficial effects
on the cardiovascular system, in part by preserving the contractile phenotype of vascular …

A microRNA perspective on cardiovascular development and diseases: an update

JF Islas, JE Moreno-Cuevas - International journal of molecular sciences, 2018 - mdpi.com
In this review, we summarize the latest research pertaining to MicroRNAs (miRs) related to
cardiovascular diseases. In today's molecular age, the key clinical aspects of diagnosing …

Loss of FoxO3a prevents aortic aneurysm formation through maintenance of VSMC homeostasis

W Lu, Y Zhou, S Zeng, L Zhong, S Zhou, H Song… - Cell death & …, 2021 - nature.com
Vascular smooth muscle cell (VSMC) phenotypic switching plays a critical role in the
formation of abdominal aortic aneurysms (AAAs). FoxO3a is a key suppressor of VSMC …