The incredible rate of increase of information in all areas of human endeavor, especially in
science, and the arrival of powerful inexpensive computers, just in time, has given rise to the …

'Acridine'along with its functional analogue 'Acridone'is the most privileged pharmacophore
in medicinal chemistry with diverse applications ranging from DNA intercalators …

Studies by Cain and co-workers in recent years have pro-vided a large number of active
experimentalantitumor drugs derived from 9-anilinoacridine (Cain & Atwell, 1974; Denny et …

In an effort to further extend the number of targets for development of antiretroviral agents,
we have used an in vitro integrase assay to investigate a variety of chemicals, including …

Nine tannins, including gallo-and ellagitannins, were evaluated as poten-tial inhibitors of
HIV replication. 1, 3, 4-Tri-O-galloylquinic acid [1], 3, 5-di-O-galloylshikimic acid {2], 3, 4, 5-tri …

An understanding of the mechanism by which minor groove binding agents interact with
DNA has led to the design of agents that can reversibly bind with high selectivity to extended …

The discovery of new non-nucleoside antiviral compounds is of significant and growing
interest for treating herpes virus infections due to the emergence of nucleoside-resistant …

Abstract DNA-Erkennung durch Fullerene: Duplex-DNA wird durch ein zweifach
funktionalisiertes Fulleren (siehe Bild) gebunden; dies ermöglicht die Exprimierung der DNA …

In a further investigation of electron-deficient DNA-intercalating ligands as antitumor drugs, a
series of substituted IV-[2-(dimethylamino) ethyl] phenazine-1-carboxamides have been …

Complexation between a ligand molecule and a nucleic acid leads to optical changes that
can be used to monitor the binding process. As these host—drug interactions frequently …