Nitric oxide (NO) signalling has pleiotropic roles in biology and a crucial function in
cardiovascular homeostasis. Tremendous knowledge has been accumulated on the …

Heart failure (HF) has become increasingly common within the elderly population,
decreasing their survival and overall quality of life. In fact, despite the improvements in …

Cardiac fibrosis is characterized by the deposition of extracellular matrix proteins in the
spaces between cardiomyocytes following both acute and chronic tissue damage events …

The third isotype of beta-adrenoreceptors (β3-AR) has recently come (back) into focus after
the observation of its expression in white and beige human adipocytes and its implication in …

G-protein coupled receptors (GPCRs) transduce a wide range of extracellular signals. They
are key players in the majority of biologic functions including vision, olfaction, chemotaxis …

The prolonged overstimulation of β-adrenergic receptors (β-ARs), a member of the G protein-
coupled receptor (GPCR) family, causes abnormalities in the density and functionality of the …

Intermittent hypoxia (IH) has a dual nature. On the one hand, chronic IH (CIH) is an important
pathologic feature of obstructive sleep apnea (OSA) syndrome (OSAS), and many studies …

Importance Left ventricular (LV) hypertrophy contributes to the onset and progression of
heart failure (HF), particularly for patients with pre-HF (stage B) for whom no treatment has …

Evidence exists that heart failure (HF) has an overall impact of 1-2% in the global population
being often associated with comorbidities that contribute to increased disease prevalence …

Background: β3-AR (β3-adrenergic receptor) stimulation improved systolic function in a
sheep model of systolic heart failure (heart failure with reduced ejection fraction [HFrEF]) …