Open-endedness in synthetic biology: a route to continual innovation for biological design

M Stock, TE Gorochowski - Science Advances, 2024 - science.org
Design in synthetic biology is typically goal oriented, aiming to repurpose or optimize
existing biological functions, augmenting biology with new-to-nature capabilities, or creating …

Molecular assembly indices of mineral heteropolyanions: some abiotic molecules are as complex as large biomolecules

RM Hazen, PC Burns, HJ Cleaves… - Journal of the …, 2024 - royalsocietypublishing.org
Molecular assembly indices, which measure the number of unique sequential steps
theoretically required to construct a three-dimensional molecule from its constituent atomic …

Shannon entropy as a robust estimator of Zipf's Law in animal vocal communication repertoires

A Kershenbaum, V Demartsev… - Methods in Ecology …, 2021 - Wiley Online Library
Abstract Information complexity in animals is an indicator of advanced communication and
an intricate socio‐ecology. Zipf's Law of least effort has been used to assess the potential …

The morphospace of language networks

LF Seoane, R Solé - Scientific reports, 2018 - nature.com
What is the nature of language? How has it evolved in different species? Are there
qualitative, well-defined classes of languages? Most studies of language evolution deal in a …

Driven progressive evolution of genome sequence complexity in Cyanobacteria

A Moya, JL Oliver, M Verdú, L Delaye, V Arnau… - Scientific reports, 2020 - nature.com
Progressive evolution, or the tendency towards increasing complexity, is a controversial
issue in biology, which resolution entails a proper measurement of complexity. Genomes are …

Clonotype pattern in T-cell lymphomas map the cell of origin to immature lymphoid precursors

A Iyer, D Hennessey, R Gniadecki - Blood advances, 2022 - ashpublications.org
Mature T-cell lymphomas (TCLs) are rare, clinically heterogeneous hematologic cancers
with high medical need. TCLs have an inferior prognosis which is attributed to poor …

Scaling of protein function across the tree of life

R Gondhalekar, CP Kempes… - Genome Biology and …, 2023 - academic.oup.com
Scaling laws are a powerful way to compare genomes because they put all organisms onto
a single curve and reveal nontrivial generalities as genomes change in size. The …

[HTML][HTML] Algorithmic networks: Central time to trigger expected emergent open-endedness

FS Abrahao, K Wehmuth, A Ziviani - Theoretical Computer Science, 2019 - Elsevier
This article investigates emergence of algorithmic complexity in computable systems that
can share information on a network. To this end, we use a theoretical approach from …

Chapter 2: What Is Life?

S Colón-Santos, A Vázquez-Salazar, A Adams… - Astrobiology, 2024 - liebertpub.com
The question “What is life?” has existed since the beginning of recorded history. However,
the scientific and philosophical contexts of this question have changed and been refined as …

The principle of uncertainty in biology: Will machine learning/artificial intelligence lead to the end of mechanistic studies?

V de Lorenzo - PLoS biology, 2024 - journals.plos.org
Molecular Biology has long tried to discover mechanisms, considering that unless we
understand the principles, we cannot develop applications. Now machine learning and …