Active methylenes in the synthesis of a pyrrole motif: An imperative structural unit of pharmaceuticals, natural products and optoelectronic materials

R Khajuria, S Dham, KK Kapoor - RSC advances, 2016 - pubs.rsc.org
Pyrrole is one of the most important azaheterocycles, due to its wide range of applications in
pharmaceuticals and optoelectronic materials, coupled with its utility as an intermediate in …

Synthetic chemistry of pyrimidines and fused pyrimidines: A review

S Mohana Roopan, R Sompalle - Synthetic Communications, 2016 - Taylor & Francis
This review is an attempt to compile the literature of various synthetic procedures of
pyrimidine analogs. Pyrimidine and its fused pyrimidine derivatives are a class of …

Synthesis of some new pyrazolo [3, 4-d] pyrimidine derivatives of expected anticancer and radioprotective activity

MM Ghorab, FA Ragab, SI Alqasoumi… - European journal of …, 2010 - Elsevier
On the account of the reported anticancer activity of pyrazolo [3, 4-d] pyrimidines, a new
series of pyrazolo [3, 4-d] pyrimidine derivatives were synthesized and tested for in-vitro …

Discovery of new pyrimido [5, 4-c] quinolines as potential antiproliferative agents with multitarget actions: Rapid synthesis, docking, and ADME studies

RA Mekheimer, SMR Allam, MA Al-Sheikh… - Bioorganic …, 2022 - Elsevier
A novel series of pyrimido [5, 4-c] quinoline derivatives variously substituted at positions 2
and 5 have been synthesized, in good to excellent yields, via rapid base-catalyzed …

A comprehensive review of N-heterocycles as cytotoxic agents

D Kumar, S Kumar Jain - Current Medicinal Chemistry, 2016 - ingentaconnect.com
Scientific community is striving to understand the role of heterocycles and fused
heterocycles in drug discovery programme due to its impact on multi-drug resistance (MDR) …

Novel quinolines and pyrimido [4, 5-b] quinolines bearing biologically active sulfonamide moiety as a new class of antitumor agents

SI Alqasoumi, AM Al-Taweel, AM Alafeefy… - European journal of …, 2010 - Elsevier
Some novel quinolines and pyrimido [4, 5-b] quinolines have been synthesized. The
structures of which were confirmed by elemental analyses and spectral data. All the target …

VEGF/VEGFR pathway inhibitors as anti-angiogenic agents: present and future

PS Sharma, R Sharma, T Tyagi - Current cancer drug targets, 2011 - ingentaconnect.com
Angiogenesis, the formation of new blood vessels from pre-existing ones, plays a central
role in the process of tumor growth and metastasis. The proliferation of endothelium and …

Synthesis of novel pyrrole and pyrrolo [2, 3-d] pyrimidine derivatives bearing sulfonamide moiety for evaluation as anticancer and radiosensitizing agents

MM Ghorab, FA Ragab, HI Heiba, HA Youssef… - Bioorganic & medicinal …, 2010 - Elsevier
Pyrroles and pyrrolo [2, 3-d] pyrimidines were reported to act as potent anticancer agents, in
this work, a series of novel 2-substituted-3-cyano-4-phenyl-pyrrole 5, 6, 11–18, and 5-phenyl …

Biscoumarin–pyrimidine conjugates as potent anticancer agents and binding mechanism of hit candidate with human serum albumin

DS Reddy, M Kongot, V Singh… - Archiv der …, 2021 - Wiley Online Library
In our continuing efforts to develop therapeutically active coumarin‐based compounds, a
series of new C4–C4′ biscoumarin–pyrimidine conjugates (1a–l) was synthesized via SN2 …

[HTML][HTML] Synthesis and anticancer activity of some fused pyrimidines and related heterocycles

SA Al-Issa - Saudi Pharmaceutical Journal, 2013 - Elsevier
On account of the reported anticancer of pyrimidine and condensed pyrimidine, a new
pyrimido [3, 2-b]-1, 2, 4, 5-tetrazine 3a, b, 5c, d, 6, 9, pyrimido [3, 2-b]-1, 2, 4-triazine 10, 11 …