Metabolic processes play a critical role in immune regulation. Metabolomics is the
systematic analysis of small molecules (metabolites) in organisms or biological samples …

The use of multi‐scale mathematical and computational models to study complex biological
processes is becoming increasingly productive. Multi‐scale models span a range of spatial …

Solid tumor dissemination from the primary site to the sites of metastasis involves tumor cell
transport through the blood or lymph circulation systems. Once the tumor cells enter the …

Specific small interfering RNAs (siRNAs) designed to silence different oncogenic pathways
can be used for cancer therapy. However, non-modified naked siRNAs have short half-lives …

Interpretations of elevated blood levels of alanine aminotransferase (ALT) for drug-induced
liver injury often assume that the biomarker is released passively from dying cells. However …

Immunological studies frequently analyze individual components (eg, signaling pathways) of
immune systems in a reductionist manner. In contrast, systems immunology aims to give a …

A crisis continues to brew within the pharmaceutical research and development (R&D)
enterprise: productivity continues declining as costs rise, despite ongoing, often dramatic …

We introduce an agent-based model of epithelial cell morphogenesis to explore the complex
interplay between apoptosis, proliferation, and polarization. By varying the activity levels of …

Characterizing the adhesive dynamics of Plasmodium falciparum infected erythrocytes (IEs)
to different endothelial cell receptors (ECRs) in flow is a big challenge considering available …

The study of epithelial morphogenesis is fundamental to increasing our understanding of
organ function and disease. Great progress has been made through study of culture systems …