Organisms alter gene expression to adapt to changes in environmental conditions such as
temperature, nutrients, inflammatory signals, and stress (Gialitakis et al. in Mol Cell Biol 30 …

Human protein kinase C (PKC) isoforms have been implicated in diseases such as
Alzheimer's, diabetes and cancers. In contrast to mammals, which have at least nine genes …

Abstract Background Lichens, encompassing 20,000 known species, are symbioses
between specialized fungi (mycobionts), mostly ascomycetes, and unicellular green algae or …

From bacteria to humans, individual cells within isogenic populations can show significant
variation in stress tolerance, but the nature of this heterogeneity is not clear. To investigate …

To cope with sudden changes in the external environment, the budding yeast
Saccharomyces cerevisiae orchestrates a multifaceted response that spans many levels of …

Studies on replicative and chronological aging in Saccharomyces cerevisiae have greatly
advanced our understanding of how longevity is regulated in all eukaryotes. Chronological …

Highlights•Chronic stresses related to biotechnology applications are focused.•Epigenetic
regulation benefits dynamic regulation of stress tolerance.•Yeast chemical stress response …

Cells respond to environmental and/or genetic perturbations in order to survive and
proliferate. Characterization of the changes after various stimuli at different-omics levels is …

Ribosome biogenesis is a crucial process for growth and constitutes the major consumer of
cellular resources. This pathway is subjected to very stringent regulation to ensure correct …

Nutrient availability and stresses impact a cell's decision to enter a growth state or a
quiescent state. Acetyl-CoA stimulates cell growth under nutrient-limiting conditions, but how …