R Vishwakarma, KJ McManus - Cancers, 2020 - mdpi.com
Chromosome instability (CIN) refers to an ongoing rate of chromosomal changes and is a driver of genetic, cell-to-cell heterogeneity. It is an aberrant phenotype that is intimately …
Aneuploidy is a ubiquitous feature of human tumors, but the acquisition of aneuploidy typically antagonizes cellular fitness. To investigate how aneuploidy could contribute to …
CC Lepage, MCL Palmer, AC Farrell… - British journal of …, 2021 - nature.com
Background High-grade serous ovarian cancer (HGSOC) is the most common and lethal ovarian cancer histotype. Chromosome instability (CIN, an increased rate of chromosome …
A Martín, C Epifano, B Vilaplana-Marti… - Cell Death & …, 2023 - nature.com
Despite being frequently observed in cancer cells, chromosomal instability (CIN) and its immediate consequence, aneuploidy, trigger adverse effects on cellular homeostasis that …
CR Morden, AC Farrell, M Sliwowski… - Gynecologic …, 2021 - Elsevier
Objective High-grade serous ovarian cancer (HGSOC) is the most lethal gynaecological malignancy in women with a high level of mortality, metastatic disease, disease recurrence …
M Bungsy, MC Palmer, LM Jeusset, NM Neudorf… - Cancer Letters, 2021 - Elsevier
Despite high-grade serous ovarian cancer (HGSOC) being the most common and lethal gynecological cancer in women, the early etiological events driving disease development …
KA Rutherford, KJ McManus - Molecular Cancer Therapeutics, 2024 - AACR
Proteolysis targeting chimeras (PROTAC) are an emerging precision medicine strategy, which targets key proteins for proteolytic degradation to ultimately induce cancer cell killing …
This review investigates the role of aneuploidy and chromosome instability (CIN) in the aging brain. Aneuploidy refers to an abnormal chromosomal count, deviating from the …
LL Thompson, AK Baergen, Z Lichtensztejn… - Cancers, 2020 - mdpi.com
Chromosome instability (CIN), or progressive changes in chromosome numbers, is an enabling feature of many cancers; however, the mechanisms giving rise to CIN remain …