Specialized subpopulations of CD4+ T cells survey major histocompatibility complex class II–
peptide complexes to control phagosomal infections, help B cells, regulate tissue …

Numerous pathogens can infect the olfactory tract, yet the pandemic caused by SARS-CoV-
2 has strongly emphasized the importance of the olfactory mucosa as an immune barrier …

T cell responses play an important role in protection against beta-coronavirus infections,
including SARS-CoV-2, where they associate with decreased COVID-19 disease severity …

A mucosal route of vaccination could prevent severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) replication at the site of infection and limit transmission. We …

Antibody-secreting plasma cells (PCs) are generated in secondary lymphoid organs but are
reported to reside in an emerging range of anatomical sites. Analysis of the transcriptome of …

The nasal mucosa is often the initial site of respiratory viral infection, replication, and
transmission. Understanding how infection shapes tissue-scale primary and memory …

Compared to intramuscular vaccines, nasally administered vaccines have the advantage of
inducing local mucosal immune responses that may block infection and interrupt …

To prevent infection by respiratory viruses and consequently limit virus circulation, vaccines
need to promote mucosal immunity. The extent to which the currently used messenger RNA …

The olfactory mucosa is a component of the nasal airway that mediates the sense of smell.
Recent studies point to an important role for the olfactory mucosa as a barrier to both …

Intranasal vaccines are anticipated to be powerful tools for combating many infectious
diseases, including SARS-CoV-2, because they induce not only systemic immunity but also …