Blood flow produces mechanical frictional forces, parallel to the blood flow exerted on the
endothelial wall of the vessel, the so-called wall shear stress (WSS). WSS sensing is …

Although the clinical demand for bioengineered blood vessels continues to rise, current
options for vascular conduits remain limited. The synergistic combination of emerging …

The pace of innovations in the field of optical trapping has ramped up in the past couple of
years. The implementation of structured light, leading to groundbreaking inventions such as …

INTRODUCTION Vertebrate development comprises multiple complex morphogenetic
processes that shape the embryonic body plan through self-organization of pluripotent stem …

Organoids derived from human pluripotent stem cells are a potentially powerful tool for high-
throughput screening (HTS), but the complexity of organoid cultures poses a significant …

Background: Angiogenesis is a dynamic process that involves expansion of a preexisting
vascular network that can occur in a number of physiological and pathological settings …

Cancer has been characterized as a genetic disease, associated with mutations that cause
pathological alterations of the cell cycle, adhesion, or invasive motility. Recently, the …

Endothelial cells are at the interface between circulating blood and tissues. This position
confers on them a crucial role in controlling oxygen and nutrient exchange and cellular …

The endothelium is the cell monolayer that lines the interior of the blood vessels separating
the vessel lumen where blood circulates, from the surrounding tissues. During embryonic …

Abstract Loss-of-function (LOF) mutations in the endothelial cell (EC)-enriched gene
endoglin (ENG) cause the human disease hereditary haemorrhagic telangiectasia-1 …