Bacteria are an exceedingly diverse group of organisms whose molecular exploration is
experiencing a renaissance. While the classical view of bacterial gene expression was …

Chemical modifications of transcripts with a 5′ cap occur in all organisms and function in
many aspects of RNA metabolism. To facilitate analysis of RNA caps, we developed a …

Chemical modification of transcripts with 5′ caps occurs in all organisms. Here, we report a
systems-level mass spectrometry-based technique, CapQuant, for quantitative analysis of an …

The chemical nature of the 5′ end of RNA is a key determinant of RNA stability, processing,
localization and translation efficiency,, and has been proposed to provide a layer of …

Bacterial and eukaryotic nuclear RNA polymerases (RNAPs) cap RNA with the oxidized and
reduced forms of the metabolic effector nicotinamide adenine dinucleotide, NAD+ and …

A hallmark of eukaryotic mRNAs has long been the 5′-end m 7 G cap. This paradigm was
recently amended by recent reports that Saccharomyces cerevisiae and mammalian cells …

The ubiquitous coenzyme nicotinamide adenine dinucleotide (NAD) decorates various
RNAs in different organisms. In the proteobacterium Escherichia coli, the NAD-cap confers …

Drugs and vaccines based on mRNA and RNA viruses show great potential and direct
translation in the cytoplasm eliminates chromosomal integration. Limitations are associated …

The recent FDA approval of the mRNA vaccine for severe acute respiratory syndrome
coronavirus (SARS‐CoV‐2) emphasizes the importance of mRNA as a powerful tool for …

The post-genomic era has provided researchers with a deluge of protein sequences.
However, a significant fraction of the proteins encoded by sequenced genomes remains …