Quiescence of adult mammalian neural stem cells: a highly regulated rest

N Urbán, IM Blomfield, F Guillemot - Neuron, 2019 - cell.com
Neural stem cells in the adult mammalian brain are the source of new neurons that
contribute to complex sensory and cognitive functions. Most adult neural stem cells are …

Regulation of adult mammalian neural stem cells and neurogenesis by cell extrinsic and intrinsic factors

S Matsubara, T Matsuda, K Nakashima - Cells, 2021 - mdpi.com
Tissue-specific stem cells give rise to new functional cells to maintain tissue homeostasis
and restore damaged tissue after injury. To ensure proper brain functions in the adult brain …

[HTML][HTML] Coordinated changes in cellular behavior ensure the lifelong maintenance of the hippocampal stem cell population

L Harris, P Rigo, T Stiehl, ZB Gaber, SHL Austin… - Cell stem cell, 2021 - cell.com
Neural stem cell numbers fall rapidly in the hippocampus of juvenile mice but stabilize
during adulthood, ensuring lifelong hippocampal neurogenesis. We show that this …

What is the relationship between hippocampal neurogenesis across different stages of the lifespan?

AM Bond, G Ming, H Song - Frontiers in Neuroscience, 2022 - frontiersin.org
Hippocampal neurogenesis has typically been studied during embryonic development or in
adulthood, promoting the perception of two distinct phenomena. We propose a perspective …

Functional heterogeneity of Wnt-responsive and hedgehog-responsive neural stem cells in the murine adult hippocampus

X Luo, M Dai, M Wang, X Wang, W Guo - Developmental Cell, 2023 - cell.com
Neural stem cells (NSCs) in the adult hippocampus are composed of multiple
subpopulations. However, their origin and functional heterogeneity are still unclear. Here …

Ontogeny of adult neural stem cells in the mammalian brain

AM Bond, G Ming, H Song - Current topics in developmental biology, 2021 - Elsevier
Neural stem cells (NSCs) persist into adulthood in the subgranular zone (SGZ) of the
dentate gyrus in the hippocampus and in the ventricular-subventricular zone (V-SVZ) of the …

Adult neural stem cells: born to last

AV Morales, H Mira - Frontiers in Cell and Developmental Biology, 2019 - frontiersin.org
The generation of new neurons is a lifelong process in many vertebrate species that
provides an extra level of plasticity to several brain circuits. Frequently, neurogenesis in the …

Transcriptional regulation of neural stem cell expansion in the adult hippocampus

N Guo, KD McDermott, YT Shih, H Zanga, D Ghosh… - Elife, 2022 - elifesciences.org
Experience governs neurogenesis from radial-glial neural stem cells (RGLs) in the adult
hippocampus to support memory. Transcription factors (TFs) in RGLs integrate physiological …

[HTML][HTML] Adult neurogenesis: a real hope or a delusion?

G Hussain, R Akram, H Anwar, F Sajid… - Neural Regeneration …, 2024 - journals.lww.com
Adult neurogenesis, the process of creating new neurons, involves the coordinated division,
migration, and differentiation of neural stem cells. This process is restricted to neurogenic …

Genetic regulatory and biological implications of the 10q24. 32 schizophrenia risk locus

J Wang, J Liu, S Li, X Li, J Yang, X Dang, C Mu, Y Li… - Brain, 2023 - academic.oup.com
Genome-wide association studies have identified 10q24. 32 as a robust schizophrenia risk
locus. Here we identify a regulatory variant (rs10786700) that disrupts binding of …