Deciphering the principles and mechanisms by which gene activity orchestrates complex
cellular arrangements in multicellular organisms has far-reaching implications for research …

Current transcriptomics technologies, including bulk RNA-seq, single-cell RNA sequencing
(scRNA-seq), single-nucleus RNA-sequencing (snRNA-seq), and spatial transcriptomics …

Background: Cardiac fibroblasts (CFs) have a central role in the ventricular remodeling
process associated with different types of fibrosis. Recent studies have shown that …

Spatial resolution of gene expression enables gene expression events to be pinpointed to a
specific location in biological tissue. Spatially resolved gene expression in tissue sections is …

Fibrosis is a hallmark of chronic disease. Although fibroblasts are involved, it is unclear to
what extent endothelial cells also might contribute. We detected increased expression of the …

Dynamic fibroblast to myofibroblast state transitions underlie the heart's fibrotic response.
Because transcriptome maturation by muscleblind-like 1 (MBNL1) promotes differentiated …

The efficiency of the repair process following ischemic cardiac injury is a crucial determinant
for the progression into heart failure and is controlled by both intra-and intercellular …

The underlying mechanisms of ventricular remodeling after myocardial infarction (MI) remain
largely unknown. In this study, we performed an integrative analysis of spatial …

Background: Surviving cells in the postinfarction border zone are subjected to intense
fluctuations of their microenvironment. Recently, border zone cardiomyocytes have been …

Endothelial to mesenchymal transition (EndMT) is a leading cause of fibrosis and disease,
however its mechanism has yet to be elucidated. The endothelium possesses a profound …