The potency of vaccines must be determined to ensure that the appropriate dose is given.
The manufacture and assessment of influenza vaccines are complicated by the continuously …

Vaccine-induced disease enhancement has been described in connection with several viral
vaccines in animal models and in humans. We investigated a swine model to evaluate …

Several vaccines are approved in the United States for seasonal influenza vaccination every
year. Here we compare the impact of repeat influenza vaccination on hemagglutination …

Recently, a new class of broadly neutralizing anti-influenza virus antibodies that target the
stalk domain of the viral hemagglutinin was discovered. As such, induction, isolation …

This study reports on the immunogenicity and biodistribution of H5 hemagglutinin (HA)-
based self-amplifying (sa) mRNA vaccines in mice. Four sa-mRNA vaccines encoding either …

Influenza viruses affect millions of people worldwide on an annual basis. Although vaccines
are available, influenza still causes significant human mortality and morbidity. Vaccines …

Dissolvable microneedle (DMN) patches for immunization have multiple benefits, including
vaccine stability and ease-of-use. However, conventional DMN fabrication methods have …

Transmission of pathogenic avian influenza viruses (AIV) from wild birds to domestic poultry
and humans is continuing in multiple countries around the world. In preparation for a …

Live-attenuated influenza virus (LAIV) vaccines may provide cross-protection against
contemporary influenza A virus (IAV) in swine. Conversely, whole inactivated virus (WIV) …

Adjuvants are key to shaping the immune response to vaccination, but to date, no adjuvant
suitable for human use has been developed for intradermal vaccines. These vaccines could …