Lung repair and regeneration: Advanced models and insights into human disease
The respiratory system acts as both the primary site of gas exchange and an important
sensor and barrier to the external environment. The increase in incidences of respiratory …
sensor and barrier to the external environment. The increase in incidences of respiratory …
Deciphering the M-cell niche: insights from mouse models on how microfold cells “know” where they are needed
D Del Castillo, DD Lo - Frontiers in Immunology, 2024 - frontiersin.org
Known for their distinct antigen-sampling abilities, microfold cells, or M cells, have been well
characterized in the gut and other mucosa including the lungs and nasal-associated …
characterized in the gut and other mucosa including the lungs and nasal-associated …
Cell Culture Differentiation and Proliferation Conditions Influence the In Vitro Regeneration of the Human Airway Epithelium
E Redman, M Fierville, A Cavard… - American Journal of …, 2024 - atsjournals.org
The human airway mucociliary epithelium can be recapitulated in vitro using primary cells
cultured in an air–liquid interface (ALI), a reliable surrogate to perform pathophysiological …
cultured in an air–liquid interface (ALI), a reliable surrogate to perform pathophysiological …
Reconstructing bat antiviral immunity using epithelial organoids
Bats are remarkably resilient to viruses with pandemic potential. To resolve largely unknown
molecular mechanisms governing their exceptional antiviral immunity, we established an …
molecular mechanisms governing their exceptional antiviral immunity, we established an …
Unveiling an Important New Cell Type in the Lung: Microfold Cells
SH Han - American Journal of Respiratory Cell and Molecular …, 2024 - atsjournals.org
Mammalian lungs are directly exposed to environmental pathogens and toxins and have
evolved complex defense mechanisms, including the mucociliary escalator and secretion of …
evolved complex defense mechanisms, including the mucociliary escalator and secretion of …
Single cell transcriptional analysis of human adenoids identifies molecular features of airway microfold cells
The nasal, oropharyngeal, and bronchial mucosa are primary contact points for airborne
pathogens like Mycobacterium tuberculosis (Mtb), SARS-CoV-2, and influenza virus. While …
pathogens like Mycobacterium tuberculosis (Mtb), SARS-CoV-2, and influenza virus. While …
Lung structural cell dynamics are altered by influenza virus infection experience leading to rapid immune protection following viral re-challenge
JC Worrell, KE Hargrave, GE Finney, C Hansell, J Cole… - bioRxiv, 2024 - biorxiv.org
Lung structural cells, including epithelial cells and fibroblasts, form barriers against
pathogens and trigger immune responses following infections such as influenza A virus …
pathogens and trigger immune responses following infections such as influenza A virus …