Strategies to address low drug solubility in discovery and development
Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …
therefore, to variability in clinical response. Despite significant efforts to “design in” …
Poly (ethylene oxide) poly (propylene oxide) poly (ethylene oxide) block copolymer surfactants in aqueous solutions and at interfaces: thermodynamics, structure …
P Alexandridis, TA Hatton - Colloids and Surfaces A: Physicochemical and …, 1995 - Elsevier
The association properties of poly (ethylene oxide)-block-poly (propyleneoxide)-block-poly
(ethylene oxide)(PEO PPO PEO) copolymers (commercially available as Poloxamers …
(ethylene oxide)(PEO PPO PEO) copolymers (commercially available as Poloxamers …
Thermoreversible networks: viscoelastic properties and structure of gels
K Nijenhuis - Advances in polymer science, 1997 - Springer
This review shows that the measurement of viscoelastic properties is a powerful tool in the
study of thermoreversible gels. Although many conclusions may be drawn about network …
study of thermoreversible gels. Although many conclusions may be drawn about network …
Molecular origins of surfactant-mediated stabilization of protein drugs
HJ Lee, A McAuley, KF Schilke, J McGuire - Advanced drug delivery …, 2011 - Elsevier
Loss of activity through aggregation and surface-induced denaturation is a significant
problem in the production, formulation and administration of therapeutic proteins …
problem in the production, formulation and administration of therapeutic proteins …
Differential scanning calorimetry investigation of the effect of salts on aqueous solution properties of an amphiphilic block copolymer (Poloxamer)
P Alexandridis, JF Holzwarth - Langmuir, 1997 - ACS Publications
Aqueous solution properties of a poly (ethylene oxide)-block-poly (propylene oxide)-block-
poly (ethylene oxide)(PEO− PPO− PEO) amphiphilic copolymer (Pluronic L64 …
poly (ethylene oxide)(PEO− PPO− PEO) amphiphilic copolymer (Pluronic L64 …
Effects of block architecture and composition on the association properties of poly (oxyalkylene) copolymers in aqueous solution
C Booth, D Attwood - Macromolecular Rapid Communications, 2000 - Wiley Online Library
A block copolymer of hydrophilic poly (ethylene oxide) and a hydrophobic poly (alkylene
oxide) can associate in dilute aqueous solution to form micelles. The results of recent …
oxide) can associate in dilute aqueous solution to form micelles. The results of recent …
Effect of additives on the micellization of PEO/PPO/PEO block copolymer F127 in aqueous solution
The micellization of an ethylene oxide-propylene oxide (PEO-PPO-PEO) symmetrical
triblock copolymer (Pluronic®) F127 (EO99PO65EO99, mol. wt. PPO= 1750,% PEO= 70) in …
triblock copolymer (Pluronic®) F127 (EO99PO65EO99, mol. wt. PPO= 1750,% PEO= 70) in …
Self-aggregation and phase behavior of poly (ethylene oxide)-poly (propylene oxide)-poly (ethylene oxide) block copolymers in aqueous solution
The phase behavior and aggregation properties of block copolymers of poly (ethylene
oxide)-poly (propylene oxide)-poly (ethylene oxide)(Pluronics, poloxamers) in aqueous …
oxide)-poly (propylene oxide)-poly (ethylene oxide)(Pluronics, poloxamers) in aqueous …
Regularized positive exponential sum (REPES) program-A way of inverting laplace transform data obtained by dynamic light scattering
J Jakeš - Collection of Czechoslovak chemical communications, 1995 - cccc.uochb.cas.cz
Computer program REPES, which has been used in treating dynamic light scattering data
for eight years but never published, and the algorithm used within it are described in detail …
for eight years but never published, and the algorithm used within it are described in detail …
Complex fluids of poly (oxyethylene) monoalkyl ether nonionic surfactants
R Dong, J Hao - Chemical reviews, 2010 - ACS Publications
Complex Fluids of Poly(oxyethylene) Monoalkyl Ether Nonionic Surfactants | Chemical Reviews
ACS ACS Publications C&EN CAS Find my institution Log In Chemical Reviews ACS …
ACS ACS Publications C&EN CAS Find my institution Log In Chemical Reviews ACS …