Nerve growth factor (NGF) is essential for the survival of sensory and sympathetic neurons
during development. However, in the adult, NGF and its interaction with tropomyosin …

Failure of analgesic drugs in clinical development is common. Along with the current
“reproducibility crisis” in pain research, this has led some to question the use of animal …

Animal sentience refers to the capacity of animals to feel both positive and negative
emotions including that of pain. As veterinary health professionals, we have a medical and …

Rationale: The robust advances in pain management for companion animals underlie the
decision of the American Animal Hospital Association (AAHA) and American Association of …

Chronic kidney disease (CKD) and degenerative joint disease are both considered common
in older cats. Information on the co-prevalence of these two diseases is lacking. This …

OBJECTIVE Toevaluate effects of gabapentin on activity levels and owner-perceived
mobility impairment and quality of life (QOL) in osteoarthritic geriatric cats. DESIGN Blinded …

Background Osteoarthritis (OA) is a common progressive joint disease in dogs and cats. The
goal of OA treatment is to reduce inflammation, minimize pain, and maintain joint function …

A literature review identified six placebo‐controlled studies of analgesics in client‐owned
cats with degenerative joint disease‐associated pain. Five studies with 96 cats had …

Introduction Degenerative joint disease and associated pain are common in cats,
particularly in older cats. There is a need for treatment options, however evaluation of …

OBJECTIVE To evaluate tramadol for treatment of signs of pain and impaired mobility in
geriatric cats with osteoarthritis. DESIGN Randomized controlled crossover trial. ANIMALS …