Increasing numbers of individuals suffer from neurodegenerative diseases, which are
characterized by progressive loss of neurons. Oxidative stress, in particular, the …

Vaccines have had a profound impact on the management and prevention of infectious
disease. In addition, the development of vaccines against chronic diseases has attracted …

Oxidative stress is known to play an important role in the pathogenesis of a number of
diseases. In particular, it is linked to the etiology of Alzheimer's disease (AD), an age-related …

Alzheimer disease (AD) is associated with multiple etiologies and pathological mechanisms,
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …

Filament assembly of amyloid-β peptides ending at residue 42 (Aβ42) is a central event in
Alzheimer's disease. Here, we report the cryo–electron microscopy (cryo-EM) structures of …

Neurodegenerative disorders and type 2 diabetes are global epidemics compromising the
quality of life of millions worldwide, with profound social and economic implications. Despite …

The Arctic mutation, encoding E693G in the amyloid precursor protein (APP) gene [E22G in
amyloid-β (Aβ)], causes dominantly inherited Alzheimer's disease. Here, we report the high …

Significance: Alzheimer disease (AD) is an age-related neurodegenerative disease. AD is
characterized by progressive cognitive impairment. One of the main histopathological …

Alzheimer's disease constitutes a rising threat to public health. Despite extensive research in
cellular and animal models, identifying the pathogenic agent present in the human brain and …

Background Epidemiological and clinical evidence suggests that an increased intake of long-
chain n-3 fatty acids protects against mortality from coronary artery disease. We aimed to test …