Owing to the relationship between extracellular vesicles (EVs) and physiological and
pathological conditions, the interest in EVs is exponentially growing. EVs hold high hopes …

Myocardial infarction (MI), caused by coronary heart disease (CHD), remains one of the
most common causes of death in the United States. Over the last few decades, scientists …

Pancreatic cancer is one of the deadliest cancers with rapid disease progression. Further
elucidation of its underlying molecular mechanisms and novel biomarkers for early detection …

Pancreatic cancer is one of the most malignant tumors. Invasion and metastasis can occur in
the early stage of pancreatic cancer, contributing to the poor prognosis. Accordingly, in this …

Pancreatic ductal adenocarcinoma (PDAC) is a malignant tumor with invasive and
metastatic characteristics and poor prognosis. Intracellular protein homeostasis is …

Despite the increased interest in secretomes associated with paracrine/autocrine
mechanisms, the majority of mass spectrometric cell secretome studies have been …

The present review deals with biomarker discovery, especially in regard to sample treatment
via combinatorial peptide ligand libraries, perhaps the only technique at present allowing …

In this review, we give an overview of the actual proteomic approaches used in the study of
cancer cells secretome. In particular, we describe the proteomic strategies to decipher …

Purpose Aberrant expression of microRNAs contributes to the progression of pancreatic
cancer by targeting downstream genes. A novel regulatory axis, miR-1224-5p/ELF3, was …

The discovery of low-and very low-abundance proteins in medical applications is
considered a key success factor in various important domains. To reach this category of …