Major recent advances and previous data have led to a plausible model of how key proteins
mediate neurotransmitter release. In this model, the soluble N-ethylmaleimide-sensitive …

SNARE proteins and Sec1/Munc18 (SM) proteins constitute the core molecular engine that
drives nearly all intracellular membrane fusion and exocytosis. While SNAREs are known to …

Membrane fusion triggered by Ca2+ is orchestrated by a conserved set of proteins to
mediate synaptic neurotransmitter release, mucin secretion and other regulated exocytic …

Munc18-1 forms a template to organize assembly of the neuronal SNARE complex that
triggers neurotransmitter release, binding first to a closed conformation of syntaxin-1 where …

The synaptic vesicle protein Synaptophysin (Syp) has long been known to form a complex
with the Vesicle associated soluble N-ethylmaleimide sensitive fusion protein attachment …

Both the timing and kinetics of neurotransmitter release depend on the positioning of
clustered Ca 2+ channels in active zones to docked synaptic vesicles on presynaptic plasma …

Munc13 catalyzes the transit of syntaxin from a closed complex with Munc18 into the ternary
SNARE complex. Here we report a new function of Munc13, independent of Munc18: it …

Research for three decades and major recent advances have provided crucial insights into
how neurotransmitters are released by Ca2+‐triggered synaptic vesicle exocytosis, leading …

Synaptic vesicles are primed into a state that is ready for fast neurotransmitter release upon
Ca 2+-binding to Synaptotagmin-1. This state likely includes trans-SNARE complexes …

Highlights•Methods to measure RRP are reviewed and their assumptions and limitations
discussed.•Action potential trains can be used to measure the physiologically relevant …