Discovered more than 30 years ago, the angiotensin AT2 receptor (AT2R) has evolved from
a binding site with unknown function to a firmly established major effector within the …

It is increasingly apparent that not only is a cure for the current worldwide diabetes epidemic
required, but also for its major complications, affecting both small and large blood vessels …

Purpose To review current literature on the renin-angiotensin system (RAS)-mediated
pathogenic mechanisms and therapeutic targets in ocular diseases. Methods A …

Local blood flow control within the central nervous system (CNS) is critical to proper function
and is dependent on coordination between neurons, glia, and blood vessels. Macroglia …

Pathological angiogenesis is a key feature of many diseases including retinopathies such as
ROP (retinopathy of prematurity) and DR (diabetic retinopathy). There is considerable …

Renin–Angiotensin System is classically recognized for its role in the control of systemic
blood pressure. However, the retina is recognized to have all the components necessary for …

Diabetic retinopathy (DR) is a leading cause of blindness in working age adults. DR has non-
proliferative stages, characterized in part by retinal neuroinflammation and ischemia, and …

Angiotensin II and aldosterone are the main effectors of the renin-angiotensin aldosterone
system (RAAS) and have a central role in hypertension as well as cardiovascular and renal …

In the present review we examine the experimental and clinical evidence for the presence of
a local renin–angiotensin system within the retina. Interest in a pathogenic role for the renin …

Beyond blood pressure control, angiotensin receptor blockers reduce common injury
mechanisms, decreasing excessive inflammation and protecting endothelial and …