JM Forbes, ME Cooper - Physiological reviews, 2013 - journals.physiology.org
It is increasingly apparent that not only is a cure for the current worldwide diabetes epidemic required, but also for its major complications, affecting both small and large blood vessels …
R Choudhary, MS Kapoor, A Singh… - Journal of current …, 2017 - Elsevier
Purpose To review current literature on the renin-angiotensin system (RAS)-mediated pathogenic mechanisms and therapeutic targets in ocular diseases. Methods A …
SA Mills, AI Jobling, MA Dixon, BV Bui… - Proceedings of the …, 2021 - National Acad Sciences
Local blood flow control within the central nervous system (CNS) is critical to proper function and is dependent on coordination between neurons, glia, and blood vessels. Macroglia …
JL Wilkinson-Berka, I Rana, R Armani… - Clinical …, 2013 - portlandpress.com
Pathological angiogenesis is a key feature of many diseases including retinopathies such as ROP (retinopathy of prematurity) and DR (diabetic retinopathy). There is considerable …
EL Fletcher, JA Phipps, MM Ward, KA Vessey… - Progress in retinal and …, 2010 - Elsevier
Renin–Angiotensin System is classically recognized for its role in the control of systemic blood pressure. However, the retina is recognized to have all the components necessary for …
DA Padovani-Claudio, CJ Ramos, ME Capozzi… - Progress in retinal and …, 2023 - Elsevier
Diabetic retinopathy (DR) is a leading cause of blindness in working age adults. DR has non- proliferative stages, characterized in part by retinal neuroinflammation and ischemia, and …
Angiotensin II and aldosterone are the main effectors of the renin-angiotensin aldosterone system (RAAS) and have a central role in hypertension as well as cardiovascular and renal …
In the present review we examine the experimental and clinical evidence for the presence of a local renin–angiotensin system within the retina. Interest in a pathogenic role for the renin …