Alzheimer's disease (AZD) is an age-associated neurodegenerative disorder and is one of
the common health issues around the globe. It is characterized by memory loss and a …

As an excellent candidate material for nano-sensitizers, gold nanostructures have shown
great potential in radiotherapy. Nevertheless, severe hypoxia and low accumulation of …

Proteins are prone to post-translational modifications at specific sites, which can affect their
physicochemical properties, and consequently also their safety and efficacy. Sources of post …

A library of 31 butyrylcholinesterase (BChE) and cathepsin B (CatB) inhibitors was screened
in vitro for inhibition of deoxyribonuclease I (DNase I). Compounds 22, 8 and 7 are among …

The concept of multitarget-directed ligands (MTDLs) has attracted considerable interest in
the development of agents against Alzheimer's disease. Cathepsin B, a cysteine protease …

Zinc is integral to diverse biological functions, acting catalytically, structurally, and
supportively in essential enzyme cycles, despite its limited amounts in the body. Targeting …

Alzheimer's Disease (AD) is the most common neurodegenerative illness in the elderly. Its
symptoms include progressive memory deterioration and loss of functional independence in …

O gênero Cryptococcus caracteriza-se por um fungo leveduriforme que é causador da
criptococose, uma infecção sistêmica que acomete principalmente indivíduos …