Understanding how gut flora influences gut-brain communications has been the subject of
significant research over the past decade. The broadening of the term “microbiota-gut-brain …

Recent advances suggest that the response of RNA metabolism to stress has an important
role in the pathophysiology of neurodegenerative diseases, particularly amyotrophic lateral …

Tau (MAPT) drives neuronal dysfunction in Alzheimer disease (AD) and other tauopathies.
To dissect the underlying mechanisms, we combined an engineered ascorbic acid …

Although women experience significantly higher tau burden and increased risk for
Alzheimer's disease (AD) than men, the underlying mechanism for this vulnerability has not …

The transition between soluble intrinsically disordered tau protein and aggregated tau in
neurofibrillary tangles in Alzheimer's disease is unknown. Here, we propose that soluble tau …

Neurodegenerative diseases cause progressive loss of cognitive and/or motor function and
pose major challenges for societies with rapidly aging populations. Human genetics studies …

Formation of membrane-less organelles via liquid-liquid phase separation is one way cells
meet the biological requirement for spatiotemporal regulation of cellular components and …

Tau is well established as a microtubule-associated protein in neurons. However, under
pathological conditions, aberrant assembly of tau into insoluble aggregates is accompanied …

The protein Tau aggregates into tangles in the brain of patients with Alzheimer's disease. In
solution, however, Tau is intrinsically disordered, highly soluble, and binds to microtubules …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are age-related
neurodegenerative disorders with shared genetic etiologies and overlapping clinical and …