The NOTCH gene was identified approximately 110 years ago. Classical studies have
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …

Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …

T cell acute lymphoblastic leukaemia (T-ALL) is an aggressive haematological malignancy
derived from early T cell progenitors. In recent years genomic and transcriptomic studies …

Cells of the osteoblast lineage affect the homing, and the number of long-term repopulating
haematopoietic stem cells,, haematopoietic stem cell mobilization and lineage determination …

Efforts to identify and annotate cancer driver genetic lesions have been focused primarily on
the analysis of protein-coding genes; however, most genetic abnormalities found in human …

T-cell acute lymphoblastic leukemia (T-ALL) is biologically distinct from its B lymphoblastic
(B-ALL) counterpart and shows different kinetic patterns of disease response. Although very …

The Krüppel-like factor (KLF) family of transcription factors regulates diverse biological
processes that include proliferation, differentiation, growth, development, survival, and …

Tumor relapse and metastasis remain major obstacles for improving overall cancer survival,
which may be due at least in part to the existence of cancer stem cells (CSCs). CSCs are …

T cell acute lymphoblastic leukemias (T-ALLs) arise from the malignant transformation of
hematopoietic progenitors primed toward T cell development, as result of a multistep …

Notch receptors influence cellular behavior by participating in a seemingly simple signaling
pathway, but outcomes produced by Notch signaling are remarkably varied depending on …