Intrinsically disordered protein regions (IDRs)-regions that do not fold into a fixed three-
dimensional structure but instead exist in a heterogeneous ensemble of conformations-have …

Biomolecular condensate formation has been implicated in a host of biological processes
and has found relevance in biology and disease. Understanding the physical principles and …

Liquid–liquid phase separation has drawn attention as many neurodegeneration or cancer-
associated proteins are able to form liquid membraneless compartments (condensates) by …

Cryogenic electron microscopy has revealed unprecedented molecular insight into the
conformations of β-sheet-rich protein amyloids linked to neurodegenerative diseases. It …

Amyloid deposition of the microtubule-associated protein tau is associated with
neurodegenerative diseases. In frontotemporal dementia with abnormal tau (FTD-tau) …

Membraneless organelles (bodies, granules, etc.) are spatially distinct sub-nuclear and
cytoplasmic foci involved in all the processes in a living cell, such as development, cell …