Polymerization of actin filaments against membranes produces force for numerous cellular
processes, such as migration, morphogenesis, endocytosis, phagocytosis and organelle …

Arp2/3 complex is an actin filament nucleation and branching machinery conserved in all
eukaryotes from yeast to human. Arp2/3 complex branched networks generate pushing …

Actin plays many well-known roles in cells, and understanding any specific role is often
confounded by the overlap of multiple actin-based structures in space and time. Here, we …

Cellular actin networks exhibit a wide range of sizes, shapes, and architectures tailored to
their biological roles. Once assembled, these filamentous networks are either maintained in …

The barbed and pointed ends of the actin filament (F-actin) are the sites of growth and
shrinkage and the targets of capping proteins that block subunit exchange, including CapZ …

Many fundamental cellular processes such as division, polarization, endocytosis, and
motility require the assembly, maintenance, and disassembly of filamentous actin (F-actin) …

The ability of cells to generate forces through actin filament turnover was an early adaptation
in evolution. While much is known about how actin filaments grow, mechanisms of their …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by Aβ-driven
synaptic dysfunction in the early phases of pathogenesis. In the synaptic context, the actin …

Cells control actin assembly by regulating reactions at actin filament barbed ends. Formins
accelerate elongation, capping protein (CP) arrests growth and twinfilin promotes …

According to the cellular actin dynamics paradigm, filaments grow at their barbed ends and
depolymerize predominantly from their pointed ends to form polar structures and do …