In-silico approaches to detect inhibitors of the human severe acute respiratory syndrome coronavirus envelope protein ion channel

MK Gupta, S Vemula, R Donde, G Gouda… - Journal of …, 2021 - Taylor & Francis
Recent outbreak of Coronavirus disease (COVID-19) pandemic around the world is
associated with 'severe acute respiratory syndrome'(SARS-CoV2) in humans. SARS-CoV2 …

Marker-assisted selection for grain number and yield-related traits of rice (Oryza sativa L.)

G Gouda, MK Gupta, R Donde, T Mohapatra… - … and molecular biology …, 2020 - Springer
Continuous rise in the human population has resulted in an upsurge in food demand, which
in turn demand grain yield enhancement of cereal crops, including rice. Rice yield is …

Computational characterization of structural and functional roles of DREB1A, DREB1B and DREB1C in enhancing cold tolerance in rice plant

R Donde, MK Gupta, G Gouda, J Kumar, R Vadde… - Amino acids, 2019 - Springer
Rice serves as the major food for almost half of the world population. Because of its origin in
the tropical and subtropical area, rice is more sensitive towards cold stress. Three homologs …

Computational approach towards understanding structural and functional role of cytokinin oxidase/dehydrogenase 2 (CKX2) in enhancing grain yield in rice plant

G Gouda, MK Gupta, R Donde, J Kumar… - Journal of …, 2020 - Taylor & Francis
Cytokinin oxidase/dehydrogenase (CKX) is the only known enzyme associated with
irreversible degradation of cytokinins in plants. CKX2 contains flavin adenine dinucleotide …

Field-and laboratory-based methods of screening salt tolerant genotypes in rice

A Gupta, BP Shaw - Crop and Pasture Science, 2021 - CSIRO Publishing
Salinity is one of the major abiotic stresses that lead to loss of billions of dollars in crop
production worldwide. The growth of rice plant is severely affected and subsequently the …

Deciphering the role of FOXP4 in long COVID: exploring genetic associations, evolutionary conservation, and drug identification through bioinformatics analysis

MK Gupta, G Gouda, R Vadde - Functional & Integrative Genomics, 2024 - Springer
Long COVID (LC) refers to a condition characterized by a variety of lingering symptoms that
persist for more than 4 to 12 weeks following the initial acute SARS-CoV-2 infection. Recent …

In silico identification of natural product inhibitors for γ‐secretase activating protein, a therapeutic target for Alzheimer's disease

MK Gupta, R Vadde - Journal of Cellular Biochemistry, 2019 - Wiley Online Library
Alzheimer's disease (AD) is clinically characterized by the aggregation of neurotoxic amyloid‐
β (Aβ) peptides in the brain. γ‐Secretase catalyzes the reaction of Aβ formation. Inhibition of …

[HTML][HTML] Characterization of haplotypes and single nucleotide polymorphisms associated with Gn1a for high grain number formation in rice plant

G Gouda, MK Gupta, R Donde, J Kumar, M Parida… - Genomics, 2020 - Elsevier
Rice serves as one of the essential staple food for half of the global human population.
However, due to rapid human population growth, there is an increase in food demand …

Computational approach to understand molecular mechanism involved in BPH resistance in Bt-rice plant

MK Gupta, R Vadde, G Gouda, R Donde… - Journal of Molecular …, 2019 - Elsevier
In silico approach was utilised to identify differentially expressed key hub genes during BPH
infestation on Bt rice plant, under laboratory conditions. Re-analysis of GSE74745 data with …

Insights into the structure–function relationship of both wild and mutant zinc transporter ZnT8 in human: a computational structural biology approach

MK Gupta, R Vadde - Journal of Biomolecular Structure and …, 2020 - Taylor & Francis
Polymorphism rs13266634 in SLC30A8 causes abnormal synthesis, maturation and
secretion of insulin, resulting in decrease in efficiency of glucose metabolism and diabetes …