Cyclic nucleotide phosphodiesterases (PDEs) are enzymes that have the unique function of
terminating cyclic nucleotide signaling by catalyzing the hydrolysis of cAMP and GMP. They …

Sexual behavior of the male rat can be described as a 'sequence': a series of behavioral
transitions eventually leading to a consummatory act: ejaculation. A 'funnel-model'is …

The arrival of Pfizer's blue pill Sildenafil in 1998 brought a great relief both to patient and
physician signalling the start of a great era of medical therapy in sexual medicine. Since …

The vas deferens, a muscular conduit conveying spermatozoa from the epididymis to the
urethra, has been used as a model tissue for smooth muscle pharmacological and …

Phosphodiesterases, particularly the type 5 isoform (PDE5), have gained recognition as
pivotal regulators of male reproductive physiology, exerting significant influence on testicular …

The therapeutic range of cyclic nucleotide phosphodiesterase 5 inhibitors (PDE5) inhibitors
is getting wider in the last years. This review study focuses on the potential employment of …

The nonspecific PDE inhibitors, particularly the methylxanthines: caffeine, pentoxifylline
(PTX), and theophylline, are known to stimulate sperm motility in vitro and have been used …

Phosphodiesterase (PDE) enzymes are widely distributed throughout the body, having
numerous effects and functions. The use of on demand PDE5 inhibitors (-Is) for the treatment …

Abstract Background and Aims The transient receptor potential cationic channel ankyrin 1
(TRPA1), a channel protein permeable to most divalent cations, has been suggested to play …

We have previously reported that infertile patients with diabetes mellitus (DM) have a
particular ultrasound features of the seminal vesicles (SV) characterized by higher fundus‐to …