Over a decade ago, it was discovered that microglia, the brain's immune cells, engulf
synaptic material in a process named microglial pruning. This term suggests that microglia …

Microglia, the resident immune cells of the central nervous system, play a crucial role in
regulating adult neurogenesis and contribute significantly to the pathogenesis of Alzheimer's …

Anxiety-associated symptoms following acute stress usually become extinct gradually within
a period of time. However, the mechanisms underlying how individuals cope with stress to …

Spatially heterogeneous synapse loss is a characteristic of many psychiatric and
neurological disorders, but the underlying mechanisms are unclear. Here, we show that …

Previously, lysosomes were primarily referred to as the digestive organelles and recycling
centers within cells. Recent discoveries have expanded the lysosomal functional scope and …

Microglia have been increasingly implicated in neurodegenerative diseases, including
amyotrophic lateral sclerosis (ALS). Dectin-1, encoded by the Clec7a gene, is highly …

Female reproductive aging affects fertility and overall health. Functional decline in mouse
ovary during reproductive aging is accompanied by estrous cycle prolongation and …

Studies suggest that vitamin D (VitD) may reduce oxidative stress (OS) in multiple sclerosis
(MS) patients. This study aimed to compare the effects of various VitD doses on OS in …

Abstract Introduction: The Efferent Vestibular System (EVS) originates in brainstem Efferent
Vestibular Nuclei (EVN) and modifies afferent vestibular signals at their source, in peripheral …

Knockdown (KD) of lipid droplet (LD) protein perilipin 2 (PLIN2) in beta cells impairs glucose-
stimulated insulin secretion (GSIS) and mitochondrial function. Here, we addressed a …