Lipids are a complex and diverse group of molecules with crucial roles in many
physiological processes, as well as in the onset, progression, and maintenance of cancers …

UDP-glycosyltransferases (UGTs) catalyze the covalent addition of sugars to a broad range
of lipophilic molecules. This biotransformation plays a critical role in elimination of a broad …

Objective Gut microbiota could influence gut, as well as hepatic and biliary immune
responses. We therefore thoroughly characterised the gut microbiota in primary sclerosing …

In this review we develop the argument that cholestatic liver diseases, particularly primary
biliary cholangitis and primary sclerosing cholangitis (PSC), evolve over time with …

Primary sclerosing cholangitis (PSC) offers unique opportunities to explore the gut–liver axis
owing to the close association between liver disease and colonic inflammation. It is well …

Abstract Background and Aims The prevalence of nonalcoholic fatty liver disease (NAFLD)
and steatohepatitis (NASH) is increasing at an alarming rate. The role of bile acids in the …

Early and differential diagnosis of intrahepatic cholangiocarcinoma (iCCA) and
hepatocellular carcinoma (HCC) by noninvasive methods represents a current clinical …

Bile acids have important roles in the regulation of lipid, glucose and energy metabolism.
Metabolic diseases linked to obesity, including type 2 diabetes mellitus and non-alcoholic …

Accumulation of bile acids (BAs) contributes significantly to the pathogenesis of primary
biliary cholangitis (PBC). Here, we sought to systematically characterize the serum and fecal …

Bile acids (BAs) are a group of chemically related steroids recognized as regulatory
molecules whose profiles can change in different physio-pathological situations. We have …