Transmembrane Cav2. 2 (N-type) voltage-gated calcium channels are genetically and
pharmacologically validated, clinically relevant pain targets. Clinical block of Cav2. 2 (eg …

Somatosensory information is processed by a complex network of interneurons in the spinal
dorsal horn. It has been reported that inhibitory interneurons that express neuropeptide Y …

Activation of neuraxial nociceptive linkages leads to a high level of encoding of the message
that is transmitted to the brain and that can initiate a pain state with its attendant emotive …

Pain that persists beyond the time required for tissue healing and pain that arises in the
absence of tissue injury, collectively referred to as nociplastic pain, are poorly understood …

Abstract Background Both Tetramethylpyrazine (TMPZ) and Astragaloside IV (AGS-IV) can
ameliorate neuronal apoptosis and neuroinflammation in CNS diseases. This study revolves …

Neuropeptide Y targets the Y1 receptor (Y1) in the spinal dorsal horn (DH) to produce
endogenous and exogenous analgesia. DH interneurons that express Y1 (Y1-INs; encoded …

Pain is a complex phenomenon that elicits somatosensory and motor reflexive responses
alongside enduring emotional and autonomic changes. Although pain serves as a protective …

Bone cancer pain (BCP) is excruciating for cancer patients, with limited clinical treatment
options and significant side effects, due to the complex and unclear pathogenesis of bone …

Nearly 80% of patients have depression and pain, which are linked to poor health-related
quality of life and frequently raise death rates. However, most patients with co-occurring …

Background Intersectional genetics have yielded tremendous advances in our
understanding of molecularly identified subpopulations and circuits within the dorsal horn in …