Recent advances in β-lactamase inhibitor chemotypes and inhibition modes

R Li, X Chen, C Zhou, QQ Dai, L Yang - European journal of medicinal …, 2022 - Elsevier
The effectiveness of β-lactam antibiotics is increasingly influenced by serine β-lactamases
(SBLs) and metallo-β-lactamases (MBLs), which can hydrolyze β-lactam antibiotics. The …

Pass the boron: benzoxaboroles as antiparasite drugs

M Zoltner, D Horn, MC Field - Trends in Parasitology, 2024 - cell.com
The development of new drug modalities has been facilitated recently by the introduction of
boron as a component of organic compounds, and specifically within a benzoxaborale …

Molecular docking analysis and evaluation of the antimicrobial properties of the constituents of Geranium wallichianum D. Don ex Sweet from Kashmir Himalaya

WR Mir, BA Bhat, MA Rather, S Muzamil… - Scientific reports, 2022 - nature.com
Geranium wallichianum D. Don ex Sweet is a well-known medicinal plant in Kashmir
Himalya. The evidence for its modern medicinal applications remains majorly unexplored …

Visible-light-driven PhSSPh-catalysed regioselective hydroborylation of α, β-unsaturated carbonyl compounds with NHC-boranes

X Liu, Y Shen, C Lu, Y Jian, S Xia, Z Gao… - Chemical …, 2022 - pubs.rsc.org
A photo-induced transition-metal-free regioselective hydroborylation of α, β-unsaturated
carbonyl compounds is developed. The PhSSPh reagent was employed as the …

Photoredox dearomative β-hydroborylation of indoles for the synthesis of borylated indolines

Y Jian, F Wen, J Shang, X Li, Z Liu, Y An… - Organic Chemistry …, 2024 - pubs.rsc.org
A photocatalysed dearomative β-hydroborylation reaction of indole derivatives with NHC-
boranes has been accomplished. This protocol shows a broad substrate scope with …

A Versatile Route to Acyl (MIDA) boronates

H Qiao, J Michalland, Q Huang… - Chemistry–A European …, 2023 - Wiley Online Library
A modular approach to highly functional acyl (MIDA) boronates is described. It involves the
generation of the hitherto unknown radical derived from acetyl (MIDA) boronate and its …

Switchable Access to Mono‐and Di‐Alkylated Boranes via Visible‐Light‐Induced Hydroboration of Alkenes with NHC‐Borane

X Wu, Y Wang, MX Zhou, Z Chen… - Advanced Synthesis …, 2023 - Wiley Online Library
A photo‐induced metal‐free radical hydroboration of various styrenes with NHC‐borane has
been developed, which can provide mono‐and di‐alkylated boranes in a selective manner …

6-Substituted Triazolyl Benzoxaboroles as Selective Carbonic Anhydrase Inhibitors: In Silico Design, Synthesis, and X-ray Crystallography

A Nocentini, A Bonardi, C Bazzicalupi… - Journal of Medicinal …, 2023 - ACS Publications
Benzoxaborole is currently a scaffold of great relevance in medicinal chemistry. In 2016, it
was reported to be a new and valuable chemotype for designing carbonic anhydrase (CA) …

Tartrolon sensing and detoxification by the Listeria monocytogenes timABR resistance operon

T Engelgeh, J Herrmann, R Jansen… - Molecular …, 2023 - Wiley Online Library
Listeria monocytogenes is a foodborne bacterium that naturally occurs in the soil.
Originating from there, it contaminates crops and infects farm animals and their consumption …

Structural analysis of the boronic acid β-lactamase inhibitor vaborbactam binding to Pseudomonas aeruginosa penicillin-binding protein 3

V Kumar, SL Viviani, J Ismail, S Agarwal, RA Bonomo… - PloS one, 2021 - journals.plos.org
Antimicrobial resistance (AMR) mediated by β-lactamases is the major and leading cause of
resistance to penicillins and cephalosporins among Gram-negative bacteria. β-Lactamases …