This Perspective is the seventh in an annual series that summarizes successful Fragment-to-
Lead (F2L) case studies published in a given year. A tabulated summary of relevant articles …

Riboswitches reside in the untranslated region of RNA and regulate genes involved in the
biosynthesis of essential metabolites through binding of small molecules. Since their …

SARS‐CoV‐2 contains a positive single‐stranded RNA genome of approximately 30 000
nucleotides. Within this genome, 15 RNA elements were identified as conserved between …

Prior research has shown an elevation in autism traits and diagnoses in individuals seen for
gender related consultation and in participants self-identifying as transgender. To …

19F NMR has emerged as a powerful tool in drug discovery, particularly in fragment-based
screens. The favorable magnetic resonance properties of the fluorine-19 nucleus, the …

The surprising discovery that RNAs are the predominant gene products to emerge from the
human genome catalyzed a renaissance in RNA biology. It is now well-understood that …

Although fragment-based drug discovery (FBDD) has been successfully implemented and
well-explored for protein targets, its feasibility for RNA targets is emerging. Despite the …

RNA is challenging to target with bioactive small molecules, particularly those of low
molecular weight that bind with sufficient affinity and specificity. In this report, we developed …

During the past decades, solution nuclear magnetic resonance (NMR) spectroscopy has
demonstrated itself as a promising tool in drug discovery. Especially, fragment-based drug …

Rapid development within the fields of both fragment‐based drug discovery (FBDD) and
medicinal targeting of RNA provides possibilities for combining technologies and methods in …