Heritable predisposition is an important cause of cancer in children and adolescents.
Although a large number of cancer predisposition genes and their associated syndromes …

Hepatocytes form a crucially important cell layer that separates sinusoidal blood from the
canalicular bile. They have a uniquely organized polarity with a basal membrane facing liver …

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths
worldwide. Although recent advances in therapeutic approaches for treating HCC have …

The liver is beyond any doubt the most important metabolic organ of the human body. This
function requires an intensive crosstalk within liver cellular structures, but also with other …

Access to specialty care has been associated with improved survival in patients with liver
disease but universal access is not always feasible. Methods of care delivery using virtual …

Alterations in metabolic pathways are a hallmark of cancer. A deeper understanding of the
contribution of different metabolites to carcinogenesis is thus vitally important to elucidate …

We studied the value of circulating tumor DNA (ctDNA) in predicting early postoperative
tumor recurrence and monitoring tumor burden in patients with hepatocellular carcinoma …

Background and Aims HCC remains a major unmet clinical need. Although activating
catenin beta‐1 (CTNNB1) mutations are observed in prominent subsets of HCC cases …

Acyl CoA Oxidase 2 (ACOX2) encodes branched-chain acyl-CoA oxidase, a peroxisomal
enzyme believed to be involved in the metabolism of branched-chain fatty acids and bile …

Background & Aims Adult patients suffering from liver disease of unknown cause represent
an understudied and underserved population. The use of whole-exome sequencing (WES) …